路易体轻度认知障碍患者心脏间碘苄胍闪烁显像的纵向变化
Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies.
作者信息
Greenfinch Gemma, Hamilton Calum A, Donaghy Paul C, Firbank Michael, Barnett Nicola A, Allan Louise, Petrides George S, Taylor John-Paul, O'Brien John T, Thomas Alan J
机构信息
Newcastle University Translational and Clinical Research Institute, Newcastle, UK; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; and University College London Hospital, London, UK.
Newcastle University Translational and Clinical Research Institute, Newcastle, UK.
出版信息
BJPsych Open. 2024 Dec 5;10(6):e223. doi: 10.1192/bjo.2024.766.
The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was -5.2% (range: -23.8% to +7.0%). The interpolated mean annual change in uptake was -1.6%.
本研究的目的是确定基线扫描正常的路易体轻度认知障碍（MCI-LB）患者在基线和随访之间心脏[123I]-间碘苄胍摄取是否有显著变化。八名诊断为可能的MCI-LB且基线扫描正常的参与者同意在基线后2至4年进行随访扫描。所有八次重复扫描均保持正常；然而，在三例中摄取量下降超过10%。基线和重复扫描之间摄取量的平均变化为-5.2%（范围：-23.8%至+7.0%）。摄取量的内插平均年变化为-1.6%。
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