Zhang Zhaochen, Zhao Rongxuan, Wu Xuhui, Ma Yunkun, He Yuxi
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Department of Rehabilitation, School of Nursing, Jilin University, Changchun, Jilin 130041, P.R. China.
Mol Med Rep. 2025 Feb;31(2). doi: 10.3892/mmr.2024.13412. Epub 2024 Dec 5.
The cornea is a clear connective tissue membrane at the front of the outer layer of the eyeball wall. It plays a crucial role in the refractive system of the eyeball, making it essential to maintain its transparency. Neovascularization and lymphangiogenesis in the cornea significantly impact corneal transparency and immune privilege. The growth of corneal neovascularization (CNV) and corneal lymphangiogenesis (CL) vessels is interconnected yet independent. Currently, there is a substantial amount of clinical and experimental research on CNV and CL vessels. However, due to the relatively recent focus on CL vessel research compared with CNV research, most scholars tend to concentrate on CNV, with few articles offering a comprehensive comparison and discussion of the two processes. The present review emphasizes the similarities and differences between CNV and CL and summarizes recent research progress on their correlation in animal models, growth characteristics, cytokine effects and related diseases.
角膜是眼球壁外层前部的一层透明结缔组织膜。它在眼球的屈光系统中起着至关重要的作用，因此保持其透明度至关重要。角膜新生血管化和淋巴管生成会显著影响角膜透明度和免疫赦免。角膜新生血管（CNV）和角膜淋巴管生成（CL）血管的生长相互关联但又相互独立。目前，关于CNV和CL血管有大量的临床和实验研究。然而，与CNV研究相比，由于对CL血管研究的关注相对较新，大多数学者倾向于关注CNV，很少有文章对这两个过程进行全面的比较和讨论。本综述强调了CNV和CL之间的异同，并总结了它们在动物模型中的相关性、生长特征、细胞因子作用及相关疾病的最新研究进展。
