Chenchula Santenna, Ghanta Mohan Krishna, Alhammadi Munirah, Mohammed Arifullah, Anitha Kuttiappan, Nuthalapati Poojith, Raju Ganji Seeta Rama, Huh Yun Suk, Bhaskar Lvks
Department of Pharmacology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Department of Pharmacology, MVJ Medical College and Research Hospital, Bangalore, 562114, Karnataka, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):4779-4801. doi: 10.1007/s00210-024-03686-4. Epub 2024 Dec 5.
Gout is a prevalent metabolic disorder characterized by increased uric acid (UA) synthesis or decreased UA clearance from the bloodstream, leading to the formation of urate crystals in joints and surrounding tissues. Hyperuricemia (HUA), the underlying cause of gout, poses a growing challenge for healthcare systems in developed and developing countries. Currently, the most common therapeutic approaches for gouty HUA primarily involve the use of allopathic or modern medicine. However, these treatments are often accompanied by adverse effects and may not be universally effective for all patients. Therefore, this systematic review aims to provide a comprehensive outline of phytochemical compounds that have emerged as alternative treatments for HUA associated with gout and to examine their specific mechanisms of action. A systematic search was conducted to identify phytochemicals that have previously been evaluated for their effectiveness in reducing HUA. From a review of > 800 published articles, 100 studies reporting on 50 phytochemicals associated with the management of HUA and gout were selected for analysis. Experimental models were used to investigate the effects of these phytochemicals, many of which exhibited multiple mechanisms beneficial for managing HUA. This review offers valuable insights for identifying and developing novel compounds that are safer and more effective for treating HUA associated with gout.
痛风是一种常见的代谢紊乱疾病，其特征是尿酸（UA）合成增加或血液中UA清除减少，导致关节及周围组织中尿酸盐晶体形成。高尿酸血症（HUA）是痛风的根本原因，对发达国家和发展中国家的医疗系统构成了日益严峻的挑战。目前，痛风性HUA最常见的治疗方法主要涉及使用对抗疗法或现代医学。然而，这些治疗方法往往伴有不良反应，而且可能并非对所有患者都普遍有效。因此，本系统评价旨在全面概述已成为与痛风相关的HUA替代治疗方法的植物化学化合物，并研究其具体作用机制。进行了系统检索，以确定先前已评估其降低HUA有效性的植物化学物质。通过对800多篇已发表文章的回顾，选择了100项报告50种与HUA和痛风管理相关的植物化学物质的研究进行分析。使用实验模型研究这些植物化学物质的作用，其中许多植物化学物质表现出多种有利于管理HUA的机制。本综述为识别和开发对治疗与痛风相关的HUA更安全、更有效的新型化合物提供了有价值的见解。
