Qin Miao, Ma Mingwen, Deng Likun, Wang Chenxu, Wang Cong
Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Anhui 234000, China.
Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Anhui 234000, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Mar 15;329:125509. doi: 10.1016/j.saa.2024.125509. Epub 2024 Nov 28.
Surface-enhanced Raman scattering (SERS) technology has been widely used in the field of analytical detection owing to its high sensitivity and fingerprint-recognition ability. However, SERS faces challenges in practical applications related to the precise control of the location of hot spots and molecules entering the hot spot regions. In this study, silver nanoparticles (AgNPs) were used to construct a novel AgNP/AgNP structure by assembling two layers of AgNP thin films using a liquid-liquid interface self-assembly method to obtain a large number of interlayer nanogap structures. A single layer of tungsten disulfide (WS) was inserted between the two layers of the AgNP thin films, and the electromagnetic field enhancement effect of the interlayer ultrasmall gaps was studied using the Raman signal of WS. The results showed that the strong near-field enhancement, generated by WS as a sub-nanometer spacer layer, mainly originated from the plasmon coupling effect between the AgNP layers; the corresponding SERS enhancement factor reached 9.72 × 10, which was much greater than the enhancement effect when WS was on a single layer of AgNPs. Finite element theoretical simulations confirmed this result. In addition, using the AgNP/AgNP interlayer small-gap structure, highly sensitive SERS detection of various target molecules was achieved. This method was also successfully applied for the detection of antibiotic residues in poultry feathers, providing a new approach for food safety monitoring. The interlayer small-gap structure proposed in this study provides a new strategy for constructing high-performance SERS substrates and is expected to promote the practical application of SERS technology in fields such as environmental monitoring and food safety.
表面增强拉曼散射（SERS）技术因其高灵敏度和指纹识别能力而在分析检测领域得到广泛应用。然而，SERS在实际应用中面临挑战，这些挑战与热点位置的精确控制以及分子进入热点区域有关。在本研究中，通过液 - 液界面自组装方法组装两层AgNP薄膜，使用银纳米颗粒（AgNPs）构建了一种新型的AgNP/AgNP结构，以获得大量的层间纳米间隙结构。在两层AgNP薄膜之间插入单层二硫化钨（WS），并利用WS的拉曼信号研究层间超小间隙的电磁场增强效应。结果表明，作为亚纳米间隔层的WS产生的强近场增强主要源于AgNP层之间的等离子体耦合效应；相应的SERS增强因子达到9.72×10，远大于WS在单层AgNPs上时的增强效果。有限元理论模拟证实了这一结果。此外，利用AgNP/AgNP层间小间隙结构实现了对各种目标分子的高灵敏度SERS检测。该方法还成功应用于家禽羽毛中抗生素残留的检测，为食品安全监测提供了一种新方法。本研究提出的层间小间隙结构为构建高性能SERS基底提供了一种新策略，有望推动SERS技术在环境监测和食品安全等领域的实际应用。
