Amunategui J P Rey, Molina E M, Pompili G A, Mas J, Pignataro O P, Miceli D D
Faculty of Veterinary Sciences, University of Buenos Aires, Argentina.
Faculty of Veterinary Sciences, University of Buenos Aires, Argentina.
Domest Anim Endocrinol. 2025 Apr;91:106898. doi: 10.1016/j.domaniend.2024.106898. Epub 2024 Nov 28.
Feline hypersomatotropism (HST) can develop in both diabetic and non-diabetic cats, but studies evaluating the prevalence of HST in cats without diabetes mellitus (DM) are lacking. The aims of the study were to evaluate circulating insulin-like growth factor 1 (IGF-1) in non-diabetic cats with chronic kidney disease (CKD), to assess whether there is a correlation between general test of renal function and IGF-1 concentration in cats with CKD, and to screen this population for the presence of HST. In this prospective study, one hundred fifty-four non-diabetic cats (n = 154) with CKD from referral centers in Buenos Aires (Argentina) were evaluated. Serum IGF-1 concentration was measured as part of the routine tests for CKD and compared with a healthy control group of 50 cats without CKD. The median serum IGF-1 concentration in the total population of cats with CKD was 500 ng/mL (range 34-1593 ng/mL). Median serum IGF-1 concentrations of cats with IRIS stage 1 (n = 13), stage 2 (n = 86), stage 3 (n = 40) and stage 4 (n = 15) of CKD were 230 ng/mL (range 58-951 ng/mL), 473 ng/mL (range 34-1456 ng/mL), 597 ng/mL (range 123-1593 ng/mL), 569 ng/mL (range 123-1045 ng/mL), respectively. None of the cats in the control group had IGF-1 concentration >1000 ng/mL (median 505 ng/mL, range 114-720 ng/mL). There was a positive linear correlation between serum IGF-1 and creatinine concentrations in cats with CKD (r= 0.22, 95% confidence interval 0.06-0.37 P=0.005). A proportion of 5.8% (95% confidence interval 2.7-10.8%) of non-diabetic cats with CKD had markedly increased IGF-1 concentrations (cut-off IGF-1 >1000 ng/mL). Pituitary enlargement was detected on computed tomography in 3/4 of these cases. Eighteen cats (11.6%) had serum IGF-1 concentrations in the "grey zone" between 800 and 1000 ng/mL. A small proportion of non-diabetic cats with CKD had an IGF-1 concentration in a range that is consistent with HST in diabetic cats. Likewise, the progression of CKD in cats without DM correlates with increases in serum IGF-1 concentrations.
猫生长激素分泌过多症（HST）在糖尿病猫和非糖尿病猫中均可发生，但缺乏对非糖尿病猫中HST患病率的评估研究。本研究的目的是评估患有慢性肾病（CKD）的非糖尿病猫的循环胰岛素样生长因子1（IGF-1）水平，评估CKD猫的肾功能常规检测指标与IGF-1浓度之间是否存在相关性，并筛查该群体中是否存在HST。在这项前瞻性研究中，对来自布宜诺斯艾利斯（阿根廷）转诊中心的154只患有CKD的非糖尿病猫（n = 154）进行了评估。血清IGF-1浓度作为CKD常规检测的一部分进行测量，并与50只无CKD的健康对照组猫进行比较。患有CKD的猫的总群体中血清IGF-1浓度中位数为500 ng/mL（范围34 - 1593 ng/mL）。CKD的IRIS 1期（n = 13）、2期（n = 86）、3期（n = 40）和4期（n = 15）的猫的血清IGF-1浓度中位数分别为230 ng/mL（范围58 - 951 ng/mL）、473 ng/mL（范围34 - 1456 ng/mL）、597 ng/mL（范围123 - 1593 ng/mL）、569 ng/mL（范围123 - 1045 ng/mL）。对照组中没有猫的IGF-1浓度>1000 ng/mL（中位数505 ng/mL，范围114 - 720 ng/mL）。CKD猫的血清IGF-1与肌酐浓度之间存在正线性相关（r = 0.22，95%置信区间0.06 - 0.37，P = 0.005）。5.8%（95%置信区间2.7 - 10.8%）的患有CKD的非糖尿病猫的IGF-1浓度显著升高（临界值IGF-1>1000 ng/mL）。在这些病例中，四分之三的病例通过计算机断层扫描检测到垂体增大。18只猫（11.6%）的血清IGF-1浓度处于800至1000 ng/mL的“灰色区域”。一小部分患有CKD的非糖尿病猫的IGF-1浓度处于与糖尿病猫HST一致的范围内。同样，无糖尿病猫的CKD进展与血清IGF-1浓度升高相关。
