Dooley J M, Goulden K J, Gatien J G, Gibson E J, Brown B S
Ann Neurol. 1986 Feb;19(2):192-4. doi: 10.1002/ana.410190214.
Inhibitors of acetylcholinesterase are commonly used in the treatment of myasthenia gravis. We studied a patient with mainly bulbar myasthenia gravis who did not tolerate oral pyridostigmine despite a clear clinical response. Treatment with nebulized pyridostigmine reduced her symptoms without systemic side effects. This route of therapy may benefit other patients.
乙酰胆碱酯酶抑制剂常用于治疗重症肌无力。我们研究了一名主要患有延髓型重症肌无力的患者，尽管临床反应明显，但她无法耐受口服吡啶斯的明。雾化吸入吡啶斯的明治疗减轻了她的症状，且无全身副作用。这种治疗途径可能对其他患者有益。
