Li Yiyuan, Du Xihao, Shi Shuxiao, Chen Meng, Wang Sujing, Huang Yue, Zhong Victor W
Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Affect Disord. 2025 Mar 1;372:262-268. doi: 10.1016/j.jad.2024.12.021. Epub 2024 Dec 3.
Comorbid depression and cardiometabolic diseases are prevalent and increase risk of mortality. However, trends in the prevalence and multimorbidity of cardiometabolic diseases in depression are unclear.
Data of adults aged ≥20 years with depression from the National Health and Nutrition Examination Survey 2005-2020 were analyzed. Joinpoint regression analysis was used to estimate trends in the prevalence of dyslipidemia, hypertension, diabetes, chronic kidney disease, non-alcoholic fatty liver disease, and cardiovascular disease as well as having ≥3 of these diseases. Differences in the prevalence of these diseases in depression vs no depression were assessed using Poisson regressions after applying propensity score weighting.
A total of 3412 adults with depression were included. The prevalence of cardiometabolic diseases as well as having ≥3 diseases remained high and stable in the overall sample from 2005 to 2020 (P for trend >0.05). In 2017-2020, the prevalence ranged from 17.1 % (95 % CI, 12.7 %-21.5 %) for cardiovascular disease to 58.4 % (95 % CI, 50.4 %-66.3 %) for dyslipidemia; 40.7 % (95 % CI, 34.4 %-46.9 %) had ≥3 diseases. The prevalence of diabetes, cardiovascular disease, and having≥3 diseases was 23 %-85 % higher in adults with depression than those without.
The utilization of self-reported data and/or one-time laboratory measurements may misclassify participants.
Prevalence of cardiometabolic diseases was high and multimorbidity was common in US adults with depression. Addressing the prevention, treatment, and management of cardiometabolic diseases in depression requires greater public health and clinical attention.
抑郁症与心脏代谢疾病共病很常见，且会增加死亡风险。然而，抑郁症患者中心脏代谢疾病的患病率及多病共患趋势尚不清楚。
对2005年至2020年美国国家健康与营养检查调查中年龄≥20岁的抑郁症成年患者数据进行分析。采用Joinpoint回归分析来估计血脂异常、高血压、糖尿病、慢性肾脏病、非酒精性脂肪性肝病和心血管疾病的患病率趋势，以及患有≥3种此类疾病的趋势。在应用倾向评分加权后，使用泊松回归评估抑郁症患者与非抑郁症患者中这些疾病患病率的差异。
共纳入3412名抑郁症成年患者。2005年至2020年，总体样本中心脏代谢疾病的患病率以及患有≥3种疾病的情况保持在高位且稳定（趋势P>0.05）。2017年至2020年，心血管疾病的患病率为17.1%（95%CI，12.7%-21.5%），血脂异常为58.4%（95%CI，50.4%-66.3%）；40.7%（95%CI，34.4%-46.9%）的患者患有≥3种疾病。抑郁症成年患者中糖尿病、心血管疾病以及患有≥3种疾病的患病率比无抑郁症者高23%-85%。
使用自我报告数据和/或一次性实验室测量可能会对参与者进行错误分类。
美国抑郁症成年患者中心脏代谢疾病患病率高，多病共患情况普遍。应对抑郁症患者心脏代谢疾病的预防、治疗和管理需要公共卫生和临床给予更多关注。
