Kanda N, Tsuchida Y, Hayashi Y, Ise T, Takayama J, Utakoji T
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 2):661-6.
N-myc, which has partial sequence homology to the oncogene c-myc, was isolated from human neuroblastoma cell lines. We have surveyed amplification of N-myc, clone 8 and pG21 in human neuroblastoma cell lines, xenografts and in primary tumors and found that amplification frequently occurred in tumors classified as stage III and IV. In situ hybridization studies demonstrated that in neuroblastomas, chromosome aberrations such as HSR (homogeneously staining region) and DMs (double minutes) are cytological manifestations of the amplification of these clones. The N-myc-related gene seems to contribute to cell growth or differentiation of the nerve cell and its amplification with enhanced expression promotes the progression of the tumor with poor prognosis.
N-myc与癌基因c-myc具有部分序列同源性，它是从人神经母细胞瘤细胞系中分离出来的。我们检测了人神经母细胞瘤细胞系、异种移植瘤及原发性肿瘤中N-myc、克隆8和pG21的扩增情况，发现扩增常见于III期和IV期肿瘤。原位杂交研究表明，在神经母细胞瘤中，诸如均一染色区（HSR）和双微体（DMs）等染色体畸变是这些克隆扩增的细胞学表现。N-myc相关基因似乎对神经细胞的生长或分化有作用，其扩增及表达增强会促进预后不良的肿瘤进展。
