Che Keying, Li Jinyu, Chen Zheng, Li Qiang, Wen Qiang, Wang Chuanxi, Yang Zhe
Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Cytokine Growth Factor Rev. 2024 Nov 22. doi: 10.1016/j.cytogfr.2024.11.005.
Interleukin-33 (IL-33) belongs to the IL-1 cytokine superfamily and plays a critical role in regulating immune responses and maintaining host homeostasis. IL-33 is essential for driving and enhancing type 2 immune responses and is closely associated with the pathogenesis of various inflammatory diseases, infections, and the progression and metastasis of cancers. This study aimed to provide an overview of the anti-tumor effects of IL-33 by examining its complex immunomodulatory functions within the tumor microenvironment and how it regulates immune cells to mediate these effects. We also provided perspectives on the pleiotropic roles of IL-33 in immunomodulation, its potential use in cancer immunotherapies, and possible adverse effects associated with its therapeutic application. Understanding these mechanisms is crucial for developing more effective IL-33-based diagnostic and therapeutic strategies.
白细胞介素-33（IL-33）属于白细胞介素-1细胞因子超家族，在调节免疫反应和维持宿主内环境稳定中起关键作用。IL-33对于驱动和增强2型免疫反应至关重要，并且与各种炎症性疾病、感染以及癌症的进展和转移的发病机制密切相关。本研究旨在通过研究IL-33在肿瘤微环境中的复杂免疫调节功能及其如何调节免疫细胞来介导这些作用，从而概述IL-33的抗肿瘤作用。我们还提供了关于IL-33在免疫调节中的多效性作用、其在癌症免疫治疗中的潜在用途以及与其治疗应用相关的可能不良反应的观点。了解这些机制对于开发更有效的基于IL-33的诊断和治疗策略至关重要。
