Winniford M D, Fulton K L, Hillis L D
Arch Intern Med. 1986 Apr;146(4):795.
To study the safety and feasibility of abruptly changing antianginal therapy from propranolol hydrochloride to verapamil, we gave propranolol to ten patients with stable angina and coronary artery disease for 14 days, then, on day 15, we began verapamil therapy, which continued for 14 more days. Anginal frequency and nitroglycerin use were similar throughout the study. No patient had symptomatic bradycardia or atrioventricular block. Such crossover therapy is effective when propranolol is replaced by verapamil abruptly.
为研究将抗心绞痛治疗从盐酸普萘洛尔突然转换为维拉帕米的安全性和可行性，我们对10例稳定型心绞痛和冠心病患者给予普萘洛尔治疗14天，然后在第15天开始维拉帕米治疗，并持续14天。在整个研究过程中，心绞痛发作频率和硝酸甘油使用情况相似。没有患者出现症状性心动过缓或房室传导阻滞。当普萘洛尔突然被维拉帕米替代时，这种交叉治疗是有效的。
