Correlation between the genotype, lifestyle habits, and cognitive deficits in Chinese adults over 60: a cross-sectional analysis in China.

INTRODUCTION

is regarded as the most significant genetic contributor linked to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Daily life elements might also influence cognitive abilities to some extent. This research aimed to investigate whether carrying alters the effects of lifestyle on cognitive ability.

METHODS

The research included 1871 senior community members with gene data, all participating in clinical, neuropsychological, and daily living factor assessments. Based on their status, they were categorized into two groups: the group ( = 362) and the group ( = 1,509). Subsequently, a multivariate logistic regression analysis was employed to investigate the link between cognitive deficits and , along with lifestyle patterns.

RESULTS

Our research revealed a reduced incidence of MCI (OR = 0.745, 95% CI: 0.587-0.945, = 0.015) and dementia (OR = 0.422, 95% CI: 0.259-0.688, = 0.001) in the non- carriers. Furthermore, the general linear regression analysis revealed a notable interplay between and sleep disturbances, potentially impacting cognitive deterioration together ( = 6.817, = 0.001).

CONCLUSIONS

The research indicates that possessing alters the impact of everyday life factors on cognitive decline. In addition, there is a significant interaction between and sleep disorders, which may jointly lead to the appearance of cognitive impairment.