Chávez-Hernández María Elena, Rodríguez-Serrano Luis Miguel, Díaz-Urbina Daniel, Muñóz-Sánchez Sinuhé, Buenrostro-Jáuregui Mario Humberto, Escartín-Pérez Rodrigo Erick
Psychology Department at the Universidad Iberoamericana Ciudad de México, Ciudad de México, Mexico.
Facultad de Estudios Superiores Iztacala, UNAM. Laboratorio de Neurobiología de la Alimentación, Tlalnepantla, Estado de México, Mexico.
Front Psychol. 2024 Nov 21;15:1468984. doi: 10.3389/fpsyg.2024.1468984. eCollection 2024.
Consumption of palatable food (PF) can lead to chronic overconsumption and obesity. Furthermore, adolescents may be vulnerable to excessively reinforcing foods, which increases the probability of developing overweight and obesity in adulthood. The role of PF availability in binge-like intake among adolescents without caloric needs remains unclear. The present study aimed to evaluate which PF access protocol is the most sensitive to induce increased caloric intake and binge-like eating during adolescence.
We used 24 male Wistar rats [30 postnatal days (PND)]; standard food and water were provided . Rats were randomly assigned to one of three groups: (a) continuous, daily access to PF; (b) intermittent, 1-day access/1-day no-access; or (c) weekend, 3 days-access/4 days no-access. All groups had 1 h access to PF (chocolate sandwich cookies). Access protocols were maintained for 6 weeks; afterward, rats underwent a 7-day withdrawal period, and were then evaluated on a binge-eating test.
Chronic restricted PF access induces binge-like intake, with intermittent access resulting in the highest binge index. Additionally, caloric intake of PF increases over time during adolescence, with differential effects of intermittent and weekend access.
Chronic restricted access to PF during adolescence induces binge-like intake, with differences depending on PF availability. This can lead to chronic overconsumption under non-homeostatic conditions.
食用美味食物（PF）会导致慢性过度消费和肥胖。此外，青少年可能易受过度强化食物的影响，这增加了成年后患超重和肥胖症的可能性。在无热量需求的青少年中，PF的可获得性在类似暴饮暴食的摄入中的作用尚不清楚。本研究旨在评估哪种PF获取方案对诱导青少年时期热量摄入增加和类似暴饮暴食最敏感。
我们使用了24只雄性Wistar大鼠[出生后30天（PND）]；提供标准食物和水。大鼠被随机分为三组之一：（a）持续每日可获取PF；（b）间歇性，1天可获取/1天不可获取；或（c）周末，3天可获取/4天不可获取。所有组都有1小时获取PF（巧克力夹心饼干）的时间。获取方案维持6周；之后，大鼠经历7天的戒断期，然后进行暴饮暴食测试评估。
长期限制PF获取会诱导类似暴饮暴食的摄入，间歇性获取导致最高的暴饮暴食指数。此外，青少年时期PF的热量摄入随时间增加，间歇性和周末获取有不同影响。
青少年时期长期限制获取PF会诱导类似暴饮暴食的摄入，具体差异取决于PF的可获得性。这可能导致在非稳态条件下的慢性过度消费。
