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围手术期胰高血糖素样肽-1受体激动剂(GLP-1RA)与胃床旁超声检查(POCUS)。

Perioperative Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RA) and Gastric Point Of Care Ultrasound (POCUS).

作者信息

Arumugam Sivasenthil, Kalagara Hari

机构信息

School of Medicine, University of Connecticut Farmington, CT USA.

Woodland Anesthesiology Associates Hartford, CT USA.

出版信息

POCUS J. 2024 Nov 15;9(2):39-41. doi: 10.24908/pocus.v9i2.17700. eCollection 2024.

DOI:10.24908/pocus.v9i2.17700
PMID:39640084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11619776/
Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are frequently used for diabetes and weight loss management. The GLP-1 RA   drugs delay gastric emptying and are a concern for increased risk of aspiration in the perioperative period. Current recommendations to hold these medications before surgery are consensus based. Gastric point of care ultrasound (POCUS)   can provide information regarding nature and volume of gastric contents in these patients during the perioperative period. In this case series, we present three patients where gastric POCUS helped formulate a safer, alternative anesthetic plan. Anesthetic management varied depending on the situation, urgency and needs of the procedure. We recommend gastric POCUS in this group of patients to provide objective assessment of gastric contents.

摘要

胰高血糖素样肽-1受体激动剂(GLP-1 RA)常用于糖尿病和体重管理。GLP-1 RA药物会延迟胃排空,这在围手术期会增加误吸风险,令人担忧。目前关于术前停用这些药物的建议是基于共识的。胃床旁超声(POCUS)可以在围手术期为这些患者提供有关胃内容物性质和容量的信息。在这个病例系列中,我们展示了三名患者,胃POCUS有助于制定更安全的替代麻醉方案。麻醉管理根据手术的情况、紧迫性和需求而有所不同。我们建议对这类患者进行胃POCUS检查,以客观评估胃内容物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/9191659c4df2/pocusj-09-02-17700-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/6b8a1bbc01b2/pocusj-09-02-17700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/3fa5882a0b10/pocusj-09-02-17700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/9191659c4df2/pocusj-09-02-17700-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/6b8a1bbc01b2/pocusj-09-02-17700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/3fa5882a0b10/pocusj-09-02-17700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce5f/11619776/9191659c4df2/pocusj-09-02-17700-g003.jpg

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本文引用的文献

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Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia.胰高血糖素样肽-1 受体激动剂的使用与麻醉前胃残留量。
JAMA Surg. 2024 Jun 1;159(6):660-667. doi: 10.1001/jamasurg.2024.0111.
2
Particulate Gastric Contents in Patients Prescribed Glucagon-Like Peptide 1 Receptor Agonists After Appropriate Perioperative Fasting: A Report of 2 Cases.服用胰高血糖素样肽 1 受体激动剂的患者的胃内容物:2 例报告。
A A Pract. 2023 Aug 24;17(8):e01712. doi: 10.1213/XAA.0000000000001712. eCollection 2023 Aug 1.
3
Anesthesia and glucagon-like peptide-1 receptor agonists: proceed with caution!
麻醉与胰高血糖素样肽-1受体激动剂:谨慎使用!
Can J Anaesth. 2023 Aug;70(8):1281-1286. doi: 10.1007/s12630-023-02550-y. Epub 2023 Jul 19.
4
Regurgitation under anesthesia in a fasted patient prescribed semaglutide for weight loss: a case report.禁食患者在接受司美格鲁肽减肥治疗时出现麻醉反流:病例报告。
Can J Anaesth. 2023 Aug;70(8):1397-1400. doi: 10.1007/s12630-023-02521-3. Epub 2023 Jun 6.
5
Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report.司美格鲁肽、胃排空延迟和术中误吸:病例报告。
Can J Anaesth. 2023 Aug;70(8):1394-1396. doi: 10.1007/s12630-023-02440-3. Epub 2023 Mar 28.
6
Relationship between perioperative semaglutide use and residual gastric content: A retrospective analysis of patients undergoing elective upper endoscopy.围手术期使用司美格鲁肽与残余胃内容物的关系:对接受择期上消化道内镜检查患者的回顾性分析
J Clin Anesth. 2023 Aug;87:111091. doi: 10.1016/j.jclinane.2023.111091. Epub 2023 Mar 2.