Genovese Sabrina Maria, Tiefenbach Jakov, Nunna Ravi A, Youkilis Andrew
Department of Neurosurgery, University of Missouri, School of Medicine, Columbia, Missouri, United States.
Department of Neurosurgery, University of Illinois, College of Medicine, Chicago, Chicago, Illinois, United States.
Surg Neurol Int. 2024 Nov 22;15:431. doi: 10.25259/SNI_795_2024. eCollection 2024.
Histiocytic neoplasms are defined by too many histiocytes accumulating in various tissues, including the skin, bones, lymph nodes, and central nervous system. They are uncommon blood-related disorders that constitute <1% of cancers found in soft tissues and lymph nodes. Most referred to as Langerhans cell histiocytosis (LCH) or non-LCH, there are over 100 different sub-types that are divided into five groups. Here, a 76-year-old male presented with an intramedullary thoracic LCH.
A 76-year-old male presented with the month of slowly progressive bilateral lower extremity weakness (i.e., right > left) accompanied by decreased left-sided sensation below the T7 level. The enhanced thoracic magnetic resonance (MR) imaging documented an intradural intramedullary nodule at the T5 level with a syrinx extending from C7 to T10. The patient underwent a T4-T6 laminectomy for complete resection of the lesion. CD163 and CD68 studies highlighted a small, spindled-shaped tumor with occasionally enlarged histiocytes without co-positivity for S100. Pathologically, the lesion was considered an isolated intramedullary thoracic LCH.
A 76-year-old male presented with progressive paraparesis of 1 month's duration attributed to an enhanced MR-documented T5 single intramedullary T5 thoracic LCH that was successfully resected.
组织细胞肿瘤的定义是在包括皮肤、骨骼、淋巴结和中枢神经系统在内的各种组织中积累了过多的组织细胞。它们是罕见的血液相关疾病，在软组织和淋巴结中发现的癌症中占比不到1%。大多数被称为朗格汉斯细胞组织细胞增多症（LCH）或非LCH，有超过100种不同的亚型，分为五组。在此，一名76岁男性出现了胸段髓内LCH。
一名76岁男性出现了持续1个月的缓慢进展性双侧下肢无力（即右侧>左侧），伴有T7水平以下左侧感觉减退。增强胸部磁共振成像（MR）显示T5水平硬膜内髓内结节，伴有从C7延伸至T10的空洞。患者接受了T4-T6椎板切除术以完全切除病变。CD163和CD68研究突出显示了一个小的、梭形肿瘤，偶尔有增大的组织细胞，S100无共阳性。病理上，该病变被认为是孤立的胸段髓内LCH。
一名76岁男性出现了持续1个月的进行性截瘫，归因于增强MR记录的T5单发性胸段髓内LCH，该病变已成功切除。
