Cordoba-Alvarado Rosana, Romero-Fonnegra Valentina, Cortes-Mejia Nicolas, Bejarano-Ramirez Diana Fernanda, Maldonado-Hoyos Valentina, Sanchez-Garcia Sandra Janeth, Vera-Torres Alonso
Clinical Psychology Section, Transplant Services, Fundacion Santa Fe de Bogotá, Bogotá, Colombia.
Transplant and Hepatobiliary Surgery Department, Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Front Transplant. 2024 Nov 21;3:1476952. doi: 10.3389/frtra.2024.1476952. eCollection 2024.
Liver transplantation (LT) improves survival in end-stage liver disease. Several reports have addressed the impact of LT on patients' lives, beyond purely medical outcomes. Although the quality of life and mental health have been demonstrated to improve with this procedure, such studies are still missing in Latin America.
Patients who received LT at the Fundación Santa Fe de Bogotá between 2017 and 2019 were assessed for quality of life (QoL), anxiety, and depression and they were followed up for one year after the procedure. Pre-transplant data were gathered at inclusion on the waiting list, while post-transplant data at 3- and 12 months after LT. European Quality of Life-5 Dimensions (EQ-5D) and European Quality of Life-Visual Analog Scale (EQ-VAS) instruments were used to evaluate QoL. The Hospital Anxiety and Depression Scale (HADS) was used for evaluating anxious and depressive symptoms.
115 recipients met the inclusion criteria. Mean pre-transplant EQ-VAS was 70.78, rising to 87.16 and 92.56 at 3- and 12-months, respectively. Improvements in all EQ-5D dimensions were found in response to LT. According to the HADS questionnaire, anxiety was reduced by 2.35 points and depression by 1.63 points after LT.
in the short term, LT is a successful strategy for enhancing QoL, anxiety, and depression in patients with liver disease. Long-term benefits must be assessed.
肝移植（LT）可提高终末期肝病患者的生存率。一些报告探讨了肝移植对患者生活的影响，而不仅仅局限于纯粹的医学结果。尽管已证明该手术可改善生活质量和心理健康，但拉丁美洲仍缺乏此类研究。
对2017年至2019年期间在波哥大圣菲基金会接受肝移植的患者进行生活质量（QoL）、焦虑和抑郁评估，并在术后随访一年。移植前的数据在纳入等待名单时收集，而移植后的数据在肝移植后3个月和12个月收集。使用欧洲生活质量五维度量表（EQ-5D）和欧洲生活质量视觉模拟量表（EQ-VAS）评估生活质量。使用医院焦虑抑郁量表（HADS）评估焦虑和抑郁症状。
115名受者符合纳入标准。移植前EQ-VAS的平均得分是70.78，在3个月和12个月时分别升至87.16和92.56。肝移植后，EQ-5D的所有维度均有所改善。根据HADS问卷，肝移植后焦虑降低了2.35分，抑郁降低了1.63分。
短期内，肝移植是改善肝病患者生活质量、焦虑和抑郁的成功策略。必须评估其长期益处。
