Shabanov M A, Spasokukotskaia O N
Arkh Patol. 1986;48(1):48-53.
Comparative morphological study of uterine cervix carcinoma in 21 patients after a intracavity radiotherapy by 252Cf and in 18 patients treated with 60Co is performed. Total focal dose in a point A in both cases was 30 Gy. Morphometric study with the calculation of a volume correlation between stroma and tumour parenchyma in the two main groups and a control (untreated) group with a subsequent determination of a damage index has been done for the assessment of therapy. Both sources of radiation had an approximately similar efficiency in the treatment of superficial exophytic forms of tumour growth. 252Cf was biologically more efficient in the treatment of the deeply invasive forms of growth. The index of damage in 252Cf and 60Co was 96.5 and 84, respectively. Likewise the alterations in the surrounding normal uterine tissues after the intracavity irradiation with fast neutrons were more pronounced than those provoked by 60Co.
对21例接受²⁵²Cf腔内放疗的宫颈癌患者和18例接受⁶⁰Co治疗的患者进行了宫颈形态学对比研究。两种情况下A点的总局部剂量均为30 Gy。为评估治疗效果，对两个主要组和一个对照组（未治疗组）进行了形态计量学研究，计算基质与肿瘤实质之间的体积相关性，并随后确定损伤指数。两种辐射源在治疗浅表外生性肿瘤生长形式方面效率大致相似。²⁵²Cf在治疗深度浸润性生长形式方面生物学效率更高。²⁵²Cf和⁶⁰Co的损伤指数分别为96.5和84。同样，快中子腔内照射后周围正常子宫组织的改变比⁶⁰Co引起的更明显。
