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本文引用的文献

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Role and function of granin proteins in diabetes mellitus.嗜铬粒蛋白在糖尿病中的作用与功能。
World J Diabetes. 2021 Jul 15;12(7):1081-1092. doi: 10.4239/wjd.v12.i7.1081.
2
The Emerging Roles of Chromogranins and Derived Polypeptides in Atherosclerosis, Diabetes, and Coronary Heart Disease.嗜铬粒蛋白及其衍生多肽在动脉粥样硬化、糖尿病和冠心病中的新作用
Int J Mol Sci. 2021 Jun 6;22(11):6118. doi: 10.3390/ijms22116118.
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2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断： 。
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31. doi: 10.2337/dc20-S002.
4
Prevalence and predictors of gestational diabetes mellitus: a nationwide multicentre prospective study.妊娠期糖尿病的患病率及其预测因素：一项全国多中心前瞻性研究。
Diabet Med. 2019 Feb;36(2):221-227. doi: 10.1111/dme.13857. Epub 2018 Nov 29.
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The Pathophysiology of Gestational Diabetes Mellitus.妊娠期糖尿病的病理生理学。
Int J Mol Sci. 2018 Oct 26;19(11):3342. doi: 10.3390/ijms19113342.
6
Gestational diabetes mellitus - literature review on selected cytokines and hormones of confirmed or possible role in its pathogenesis.妊娠期糖尿病——关于已证实或可能在其发病机制中起作用的特定细胞因子和激素的文献综述。
Ginekol Pol. 2018;89(9):522-527. doi: 10.5603/GP.a2018.0089.
7
Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism.血糖异常的嗜铬粒蛋白A片段胰腺抑素的新靶点发现：与伴侣蛋白GRP78相互作用以影响代谢
PLoS One. 2014 Jan 20;9(1):e84132. doi: 10.1371/journal.pone.0084132. eCollection 2014.
8
Global estimates of the prevalence of hyperglycaemia in pregnancy.全球妊娠期高血糖症患病率的估计。
Diabetes Res Clin Pract. 2014 Feb;103(2):176-85. doi: 10.1016/j.diabres.2013.11.003. Epub 2013 Dec 1.
9
Pancreastatin is an endogenous peptide that regulates glucose homeostasis.胰淀素是一种内源性肽，可调节葡萄糖稳态。
Physiol Genomics. 2013 Nov 15;45(22):1060-71. doi: 10.1152/physiolgenomics.00131.2013. Epub 2013 Sep 24.
10
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.国际糖尿病与妊娠研究组协会关于妊娠期间高血糖的诊断和分类的建议
Diabetes Care. 2010 Mar;33(3):676-82. doi: 10.2337/dc09-1848.

妊娠糖尿病患者血浆胰抑制素水平与胰岛素抵抗的关系。

The association of plasma pancreastatin levels with insulin resistance in patients with gestational diabetes mellitus.

作者信息

Unal Kocabas Gokcen, Yildirim Simsir Ilgin, Sarer Yurekli Banu, Suner Karakulah Asli, Durmaz Burak, Pehlivan Koroglu Esma, Yeral Sena, Ozcan Busra, Akdemir Ali

机构信息

Division of Endocrinology and Metabolism Disorders, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.

Department of Biostatistics and Medical Informatics, Faculty of Medicine, Ege University, Izmir, Turkey.

出版信息

Obstet Med. 2024 Dec;17(4):221-225. doi: 10.1177/1753495X231216032. Epub 2023 Nov 19.

DOI:10.1177/1753495X231216032
PMID:39640952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11615989/
Abstract

INTRODUCTION

Gestational diabetes mellitus (GDM) occurs on the background of increased insulin resistance. We aimed to investigate the levels of plasma pancreastatin (PST) levels and its association with metabolic, demographic, and anthropometric parameters in gestational diabetic and normal glucose-tolerant pregnant women.

MATERIALS AND METHODS

A total of 165 pregnant women in the 24th-28th week of pregnancy were enrolled in this cross-sectional study. PST levels were measured using ELISA method.

RESULTS

Median PST levels were similar between GDM (n = 62, 37.6%) and normal glucose-tolerant control group (n = 103, 62.4%). In the GDM group, PST level showed a significant positive correlation with fasting insulin and the homeostasis model assessment of insulin resistance (HOMA-IR). In binary logistic regression analysis, PST levels did not predict the presence of GDM significantly.

CONCLUSION

Positive correlation of PST with fasting insulin and HOMA-IR suggests that PST could be associated with insulin resistance. Further studies are needed as regards to the role of PST in GDM pathogenesis.

摘要

引言

妊娠期糖尿病（GDM）发生于胰岛素抵抗增加的背景下。我们旨在研究妊娠糖尿病和糖耐量正常的孕妇血浆胰抑制素（PST）水平及其与代谢、人口统计学和人体测量学参数的关系。

材料与方法

本横断面研究共纳入165例妊娠24至28周的孕妇。采用酶联免疫吸附测定法（ELISA法）测量PST水平。

结果

GDM组（n = 62，37.6%）和糖耐量正常对照组（n = 103，62.4%）的PST水平中位数相似。在GDM组中，PST水平与空腹胰岛素及胰岛素抵抗稳态模型评估（HOMA-IR）呈显著正相关。在二元逻辑回归分析中，PST水平不能显著预测GDM的存在。

结论

PST与空腹胰岛素和HOMA-IR的正相关表明PST可能与胰岛素抵抗有关。关于PST在GDM发病机制中的作用还需要进一步研究。