Bian Linjie, Xu Junyan, Li Panli, Bai Liyan, Song Shaoli
From the Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, 270 Dongan Road, Xuhui District, 200032 Shanghai, China; and Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.
Radiol Imaging Cancer. 2025 Jan;7(1):e240059. doi: 10.1148/rycan.240059.
Purpose To evaluate the diagnostic performance of gallium 68 (Ga)-DOTA-NaI3-octreotide (Ga-DOTANOC) and fluorine 18 (F)-fluoro-l-3,4-dihydroxyphenylalanine (F-FDOPA) PET/CT in detecting recurrent or metastatic paragangliomas. Materials and Methods This single-center retrospective study included patients with paragangliomas who underwent both Ga-DOTANOC PET/CT and F-FDOPA PET/CT between August 2021 and December 2023. The diagnostic performance of these two tracers in detecting recurrent or metastatic tumors was compared using several metrics, including sensitivity, negative predictive value, and accuracy. Results This study included 36 patients (median age, 52 years [range, 14-78 years]; 16 female, 20 male). Of these, nine underwent initial Ga-DOTANOC and F-FDOPA PET/CT examinations before treatment, and the remaining 27 underwent posttreatment examinations. Twenty-two of those 27 patients had recurrence or metastasis. According to lesion-level analysis, Ga-DOTANOC had higher sensitivity, negative predictive value, and accuracy for diagnosis of bone metastases than did F-FDOPA PET/CT (97% vs 78% [ < .001], 85% vs 42% [ = .02], and 97% vs 81% [ < .001], respectively). F-FDOPA PET/CT had higher sensitivity, negative predictive value, and accuracy for the diagnosis of liver metastases than did Ga-DOTANOC PET/CT (73% vs 15% [ < .001], 68% vs 41% [ = .04], and 83% vs 46% [ < .001], respectively). According to patient-level analysis, the sensitivity of F-FDOPA PET/CT for diagnosing liver metastases was higher than that of Ga-DOTANOC PET/CT (88% vs 25%; = .04). Conclusion In patients with recurrent or metastatic paragangliomas, Ga-DOTANOC PET/CT showed better performance than F-FDOPA PET/CT in detecting bone metastases, and F-FDOPA PET/CT performed better in detecting liver metastases. Ga-DOTANOC, F-FDOPA, Pheochromocytoma, Paraganglioma Published under a CC BY 4.0 license.
目的 评估镓68（Ga）-DOTA-碘化钠3-奥曲肽（Ga-DOTANOC）和氟18（F）-氟-L-3,4-二羟基苯丙氨酸（F-FDOPA）PET/CT在检测复发性或转移性副神经节瘤中的诊断性能。材料与方法 这项单中心回顾性研究纳入了2021年8月至2023年12月期间接受Ga-DOTANOC PET/CT和F-FDOPA PET/CT检查的副神经节瘤患者。使用包括敏感性、阴性预测值和准确性等多种指标比较这两种示踪剂在检测复发性或转移性肿瘤中的诊断性能。结果 本研究纳入36例患者（中位年龄52岁[范围14 - 78岁]；女性16例，男性20例）。其中，9例在治疗前接受了初始Ga-DOTANOC和F-FDOPA PET/CT检查，其余27例接受了治疗后检查。这27例患者中有22例出现复发或转移。根据病灶水平分析，Ga-DOTANOC在诊断骨转移方面的敏感性、阴性预测值和准确性均高于F-FDOPA PET/CT（分别为97%对78%[<.001]，85%对42%[=.02]，97%对81%[<.001]）。F-FDOPA PET/CT在诊断肝转移方面的敏感性、阴性预测值和准确性高于Ga-DOTANOC PET/CT（分别为73%对15%[<.001]，68%对41%[=.04]，83%对46%[<.001]）。根据患者水平分析，F-FDOPA PET/CT诊断肝转移的敏感性高于Ga-DOTANOC PET/CT（88%对25%；=.04）。结论 在复发性或转移性副神经节瘤患者中，Ga-DOTANOC PET/CT在检测骨转移方面表现优于F-FDOPA PET/CT，而F-FDOPA PET/CT在检测肝转移方面表现更佳。Ga-DOTANOC、F-FDOPA、嗜铬细胞瘤、副神经节瘤 依据知识共享署名4.0许可协议发布。
