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In the Wake of OCEANIC-AF, Is Equipoise Regarding Factor XI Inhibition Still Afloat?

作者信息

Gibson C Michael

机构信息

Baim Institute for Clinical Research, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

J Am Coll Cardiol. 2025 Mar 25;85(11):1210-1212. doi: 10.1016/j.jacc.2024.10.105. Epub 2024 Dec 4.

DOI:10.1016/j.jacc.2024.10.105
PMID:39641734
Abstract
摘要

相似文献

1
In the Wake of OCEANIC-AF, Is Equipoise Regarding Factor XI Inhibition Still Afloat?在OCEANIC-AF试验之后,对于XI因子抑制的 equipoise(该词可能是特定医学术语,暂无法准确翻译,保留原文)是否仍然存在?
J Am Coll Cardiol. 2025 Mar 25;85(11):1210-1212. doi: 10.1016/j.jacc.2024.10.105. Epub 2024 Dec 4.
2
A Systematic Review of Factor XI/XIa Inhibitors Versus Direct Oral Anticoagulants in Patients with Atrial Fibrillation.心房颤动患者中因子XI/XIa抑制剂与直接口服抗凝剂的系统评价
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251335967. doi: 10.1177/10760296251335967. Epub 2025 Apr 15.
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Factor XI inhibitors and atrial fibrillation: imminent breakthrough or false start?凝血因子XI抑制剂与心房颤动:即将取得突破还是只是虚晃一枪?
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OCEANIC-AF trial: factor XI inhibitors revolution in atrial fibrillation is on hold.大洋洲房颤试验:XI因子抑制剂在房颤治疗方面的变革暂停。
Eur Heart J Cardiovasc Pharmacother. 2024 Nov 6;10(7):575-577. doi: 10.1093/ehjcvp/pvae065.
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Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use: A Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial.根据既往口服抗凝药使用情况,比较阿孙地昔或阿哌沙班用于房颤患者:OCEANIC-AF随机临床试验的亚组分析
JAMA Cardiol. 2025 Mar 26. doi: 10.1001/jamacardio.2025.0277.
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Will Factor XI Inhibitors Replace Current Anticoagulants for Stroke Prevention in Atrial Fibrillation?XI 因子抑制剂会取代当前的抗凝剂用于房颤卒中预防吗?
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Factor XIa inhibition in atrial fibrillation: insights and knowledge gaps emerging from the PACIFIC-AF trial.心房颤动中因子XIa抑制作用:来自PACIFIC-AF试验的见解与知识空白
Cardiovasc Res. 2023 Mar 17;119(1):e111-e114. doi: 10.1093/cvr/cvac196.
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Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts.肾功能障碍作为非瓣膜性心房颤动患者中风和全身性栓塞的预测因子:ROCKET AF(利伐沙班每日一次,口服,直接 Xa 因子抑制与维生素 K 拮抗剂预防中风和房颤试验)和 ATRIA(心房颤动抗凝和危险因素)研究队列中 R(2)CHADS(2)指数的验证。
Circulation. 2013 Jan 15;127(2):224-32. doi: 10.1161/CIRCULATIONAHA.112.107128. Epub 2012 Dec 3.
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Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS.社区居住成年人中凝血因子XI水平与心血管事件及心脏功能的关联:来自动脉粥样硬化风险社区研究(ARIC)和心血管健康研究(CHS)
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10
Apixaban versus Antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated intraCerebral HaEmorrhage in patients with Atrial Fibrillation (APACHE-AF): study protocol for a randomised controlled trial.阿哌沙班与抗血小板药物或房颤患者抗凝相关脑出血后不使用抗血栓药物对比研究(APACHE-AF):一项随机对照试验的研究方案
Trials. 2015 Sep 4;16:393. doi: 10.1186/s13063-015-0898-4.

引用本文的文献

1
Factor XI and Atrial Fibrillation: A Mismatched Pairing?因子XI与心房颤动:不匹配的组合?
Eur Cardiol. 2025 Apr 10;20:e08. doi: 10.15420/ecr.2024.61. eCollection 2025.
2
Factor XI inhibitors and atrial fibrillation: imminent breakthrough or false start?凝血因子XI抑制剂与心房颤动:即将取得突破还是只是虚晃一枪?
Eur Heart J Suppl. 2025 Apr 16;27(Suppl 3):iii46-iii53. doi: 10.1093/eurheartjsupp/suaf015. eCollection 2025 Mar.