Yang Chao, Xue Yimin, You Zhebin, Huang Tingfeng, He Xiaofang, Jiang Xinda, Huang Jianmin, Chen Yu, Zhou Xiao-Fen
Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, People's Republic of China.
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
PLoS One. 2024 Dec 6;19(12):e0313937. doi: 10.1371/journal.pone.0313937. eCollection 2024.
Previous studies have shown that both age and hemoglobin are closely associated with the prognosis of septic shock. A recent study found that hemoglobin may change with age. Hemoglobin-to-Age Ratio (HAR) takes both age and hemoglobin into consideration as essential factors. So far, the effect of HAR on the prognosis of septic shock is still unclear. This research aimed to investigate the association between the HAR and the prognosis of patients with septic shock.
Cox proportional hazards regression analysis, restricted cubic spline, Kaplan-Meier survivor analysis and stratified interaction analysis were used to elucidate the relationship between the HAR and prognosis of patients with septic shock.
There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was lower than 0.13, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was higher than 0.13, the HAR was not a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation.
There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was at high levels, the HAR might not be a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation.
既往研究表明，年龄和血红蛋白均与感染性休克的预后密切相关。最近一项研究发现血红蛋白可能随年龄变化。血红蛋白与年龄比值（HAR）将年龄和血红蛋白都作为重要因素考虑在内。迄今为止，HAR对感染性休克预后的影响仍不明确。本研究旨在探讨HAR与感染性休克患者预后之间的关联。
采用Cox比例风险回归分析、限制性立方样条分析、Kaplan-Meier生存分析和分层交互分析来阐明HAR与感染性休克患者预后之间的关系。
HAR与重症监护病房入院后28天内的死亡率之间存在非线性关联。当HAR低于0.13时，重症监护病房入院后28天内的死亡率随着HAR的升高而显著降低。当HAR高于0.13时，HAR并非重症监护病房入院后28天内死亡率的保护因素。在感染性休克患者中，HAR在降低房颤患者死亡风险方面比未患房颤的患者更有效。
HAR与重症监护病房入院后28天内的死亡率之间存在非线性关联。当HAR处于低水平时，重症监护病房入院后28天内的死亡率随着HAR的升高而显著降低。当HAR处于高水平时，HAR可能并非重症监护病房入院后28天内死亡率的保护因素。在感染性休克患者中，HAR在降低房颤患者死亡风险方面比未患房颤的患者更有效。
