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口服抗凝治疗的髋部骨折患者的治疗及预后

Treatment and outcome after hip fracture for patients on oral anticoagulation.

作者信息

Wilton Alexander, Sorial Ayman, Jamadar Tanzeelah, Parker Martyn

机构信息

North West Anglia Foundation Trust, Peterborough, United Kingdom.

出版信息

Injury. 2025 Feb;56(2):112072. doi: 10.1016/j.injury.2024.112072. Epub 2024 Nov 30.

Abstract

AIMS

An increasing number of patients with hip fracture are taking oral anticoagulation medication including direct oral anticoagulants (DOAC). The management of these patients regarding the timing of surgery and occurrence of complications remains contentious. The aim of this study was to compare treatment and outcomes for hip fracture patients taking anticoagulation.

METHODS

Data from a consecutive series of 3,707 hip fracture patients admitted to a single centre was collected over a seven-year period.

RESULTS

The proportion of patients taking warfarin fell slightly over the study period (6.1 % to 4.7 %) whilst the proportion taking DOAC increased greatly (1.4 % to 11.4 %). Patients on oral anticoagulation were slight older (mean age 83 years for warfarin, 85 years for DOAC versus 80 years for those not on anticoagulation), more likely to have atrial fibrillation, less likely to take anti-platelet medication and less likely to have spinal anaesthesia. Patients taking oral anticoagulant had an increased delay to theatre (mean hours admission to theatre 37.9 for warfarin, 39.5 for DOAC, 31.1 for no anticoagulation). There was no difference in the number of patients transfused, wound complications, post-operative haemoglobin or 30 -day mortality between groups.

CONCLUSION

Current policies on the timing of surgery and anticoagulation are safe.

摘要

目的

越来越多的髋部骨折患者正在服用口服抗凝药物,包括直接口服抗凝剂(DOAC)。这些患者在手术时机和并发症发生方面的管理仍存在争议。本研究的目的是比较服用抗凝剂的髋部骨折患者的治疗情况和结局。

方法

收集了一个单一中心在七年期间收治的连续3707例髋部骨折患者的数据。

结果

在研究期间,服用华法林的患者比例略有下降(从6.1%降至4.7%),而服用DOAC的患者比例大幅上升(从1.4%升至11.4%)。服用口服抗凝剂的患者年龄稍大(华法林组平均年龄83岁,DOAC组85岁,未服用抗凝剂组80岁),更有可能患有房颤,服用抗血小板药物的可能性较小,接受脊髓麻醉的可能性较小。服用口服抗凝剂的患者手术延迟时间增加(华法林组入院至手术的平均小时数为37.9,DOAC组为39.5,未服用抗凝剂组为31.1)。各组之间输血患者数量、伤口并发症、术后血红蛋白或30天死亡率没有差异。

结论

目前关于手术时机和抗凝的政策是安全的。

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