Winkelmann E, Raether W
Arzneimittelforschung. 1986 Feb;36(2):234-47.
Basically substituted 2,6- and 2,7-bis-amino-methylanthraquinones have a pronounced in vitro and in vivo effect against Entamoeba hystolytica (extraintestinal amoebiasis in golden hamsters) and marked interferon-inducing properties. In 2,6- and 2,7-bis-aminomethyl-anthraquinones only the introduction of hydroxyl groups in 1,5 or 1,8 position led to an additional high systemic activity against Trichomonas foetus in NMRI mice, but it also resulted in the loss of the interferon-inducing effect. Both substance classes included several compounds whose effects against E. histolytica or T. foetus were either comparable or superior to those of standard compounds ornidazole and tinidazole.
基本取代的2,6 - 和2,7 - 双氨基甲基蒽醌对溶组织内阿米巴（金黄仓鼠肠外阿米巴病）具有显著的体外和体内作用，并且具有明显的干扰素诱导特性。在2,6 - 和2,7 - 双氨基甲基蒽醌中，仅在1,5或1,8位引入羟基会导致对NMRI小鼠体内胎儿三毛滴虫产生额外的高全身活性，但这也导致干扰素诱导作用丧失。这两类物质都包含几种化合物，它们对溶组织内阿米巴或胎儿三毛滴虫的作用与标准化合物奥硝唑和替硝唑相当或更优。
