Duong Khanh Linh, Bui Duc Manh, Dang Khanh Linh, Nguyen Manh Cuong, Pham Thi Huong Quynh, Tran Thi Huyen Trang, Vo Thi Thuy, Du Pham Van, Doan Van Duc, Hoang Nang Trong, Tran Thi Van Anh, Tran Xuan Thuy, Nguyen Thi Hanh, Nguyen Trung Kien, Bui Thi Han, Gautret Philippe, Hoang Van Thuan, Dao Thi Loi
Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.
IHU-Méditerranée Infection, Marseille, France.
Trop Med Int Health. 2025 Jan;30(1):51-56. doi: 10.1111/tmi.14068. Epub 2024 Dec 7.
To investigate the differences in clinical, radiological and laboratory parameters between elderly and young patients with newly diagnosed smear-positive pulmonary tuberculosis in Vietnam.
This retrospective analysis included all patients hospitalised with newly diagnosed pulmonary tuberculosis with acid-fast bacilli-positive smear. Clinical symptoms, laboratory results and chest X-ray findings were collected using a standardised questionnaire. Elderly was defined as those patients aged 65 years and older.
A total of 183 patients diagnosed with new acid-fast bacilli-positive pulmonary tuberculosis were included in this study, with a mean age of 56.2 ± 16.3 years (minimum = 18 and maximum = 87 years). Seventy-seven participants were aged ≥65 years, accounting for 42.1% of participants. A total of 147 (80.3%) patients were male, and the sex ratio of male/female was 4.1. Night sweats were statistically more frequent among younger patients (34.9% vs. 20.8%, p = 0.04), whereas muscle and joint pain were more predominant among the elderly (7.6% vs. 22.1%, p = 0.01). A proportion of 67.0% of younger patients and 63.6% of the elderly group were bilaterally affected. Cavitation lesions were significantly more frequent in the younger group (55.7% vs. 39.0%, p = 0.03), whereas pulmonary fibrosis occurred more frequently in elderly patients (29.3% vs. 45.4%, p = 0.02). No other significant differences in clinical symptoms, laboratory results and chest X-ray findings were observed.
These findings underscore the importance of considering age-related variations in the clinical and radiological presentation of tuberculosis, which can guide tailored approaches in diagnosis, management and treatment strategies for different age groups.
探讨越南新诊断的涂片阳性肺结核老年患者与年轻患者在临床、放射学和实验室参数方面的差异。
这项回顾性分析纳入了所有因新诊断为肺结核且抗酸杆菌涂片阳性而住院的患者。使用标准化问卷收集临床症状、实验室结果和胸部X线检查结果。老年人定义为年龄在65岁及以上的患者。
本研究共纳入183例新诊断为抗酸杆菌阳性肺结核的患者，平均年龄为56.2±16.3岁（最小18岁，最大87岁）。77名参与者年龄≥65岁，占参与者的42.1%。共有147例（80.3%）患者为男性，男女比例为4.1。盗汗在年轻患者中在统计学上更为常见（34.9%对20.8%，p=0.04），而肌肉和关节疼痛在老年人中更为突出（7.6%对22.1%，p=0.01）。67.0%的年轻患者和63.6%的老年组患者双侧受累。空洞性病变在年轻组中明显更常见（55.7%对39.0%，p=0.03），而肺纤维化在老年患者中更常见（29.3%对45.4%，p=0.02）。在临床症状、实验室结果和胸部X线检查结果方面未观察到其他显著差异。
这些发现强调了考虑结核病临床和放射学表现中与年龄相关差异的重要性，这可为不同年龄组的诊断、管理和治疗策略提供针对性方法。
