Hoffman W E, Miletich D J, Albrecht R F
Alcohol. 1986 Jan-Feb;3(1):23-6. doi: 10.1016/0741-8329(86)90067-4.
The purpose of these experiments was to determine the effect of ethanol dose and time of administration on cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2). CBF and CMRO2 were measured in Sprague-Dawley rats 30 and 90 minutes after intraperitoneal injections of ethanol. Blood alcohol concentrations ranged from 1 to 3 mg/ml and were equivalent at both time periods. Ethanol produced small but significant increases in CBF and CMRO2 with blood alcohol concentrations. The above changes were not time dependent and were similar between 30 and 90 minute testing periods. The dose dependent effects of ethanol on cerebral metabolism are consistent with in vitro studies suggesting a dose related effect of ethanol on neuronal metabolism. The time of application appears to have little effect on the cerebral metabolic effects of alcohol.
这些实验的目的是确定乙醇剂量和给药时间对脑血流量（CBF）和脑氧耗量（CMRO2）的影响。在腹腔注射乙醇后30分钟和90分钟，对斯普拉格-道利大鼠的CBF和CMRO2进行了测量。血乙醇浓度范围为1至3mg/ml，在两个时间段均相当。随着血乙醇浓度升高，乙醇使CBF和CMRO2出现小幅但显著的增加。上述变化与时间无关，在30分钟和90分钟的测试时间段内相似。乙醇对脑代谢的剂量依赖性效应与体外研究一致，提示乙醇对神经元代谢存在剂量相关效应。给药时间似乎对酒精的脑代谢效应影响不大。
