Walker P R, James M A, Wilde R P, Wood C H, Rees J R
Br Heart J. 1986 Apr;55(4):321-9. doi: 10.1136/hrt.55.4.321.
A new stress test for thallium-201 myocardial imaging in which pharmacological coronary vasodilatation with dipyridamole is combined with dynamic exercise is described. In 38 patients with coronary artery disease the sensitivity, total number of defects, degree of redistribution, and visual quality of thallium-201 imaging were greater after dipyridamole with exercise testing than after exercise alone. When the data from these 38 patients were combined with the results of dipyridamole-exercise imaging in 49 patients in whom exercise electrocardiography had been inconclusive then the technique gave a sensitivity for coronary disease of 87% and a specificity of 92%. Dipyridamole also increased the sensitivity of the exercise electrocardiogram, so that no patient with coronary disease had a strictly negative dipyridamole-exercise stress test. Only five of 214 patients who have now undergone this test have had complications requiring reversal of vasodilatation with aminophylline. The combined use of dipyridamole and exercise in this simple technique is a reliable and safe improvement on standard thallium-201 imaging tests.
本文描述了一种用于铊 - 201心肌显像的新应激试验，该试验将双嘧达莫介导的药物性冠状动脉血管舒张与动态运动相结合。在38例冠状动脉疾病患者中，与单纯运动试验相比，双嘧达莫联合运动试验后铊 - 201显像的敏感性、缺损总数、再分布程度及视觉质量更高。当将这38例患者的数据与49例运动心电图检查结果不明确患者的双嘧达莫 - 运动显像结果相结合时，该技术对冠心病的敏感性为87%，特异性为92%。双嘧达莫还提高了运动心电图的敏感性，因此没有冠心病患者的双嘧达莫 - 运动应激试验结果为严格阴性。在目前接受该试验的214例患者中，只有5例出现了需要用氨茶碱逆转血管舒张的并发症。在这种简单技术中联合使用双嘧达莫和运动，是对标准铊 - 201显像试验的可靠且安全的改进。
