Fan Zongshan, Mao Zidong, Liu Mengya, Fu Bingbing, Yuan Xiao, Wang Lai
Henan Vocational College of Agriculture, Zhengzhou, Henan 451450, PR China.
Henan International Joint Laboratory of Neurological Diseases, The First Affiliated Hospital, Henan University, Kaifeng, Henan 475004, PR China.
J Stroke Cerebrovasc Dis. 2025 Jan;34(1):108176. doi: 10.1016/j.jstrokecerebrovasdis.2024.108176. Epub 2024 Dec 5.
To systematically evaluate the association between the rs751141 polymorphism in soluble epoxide hydrolase (sEH) and the risk of ischemic stroke and hypertension.
We searched PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chongqing VIP for eligible studies published through March 2024. Studies were selected based on inclusion and exclusion criteria. The quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS) and Joanna Briggs Institute (JBI) tools. Data extraction and meta-analysis were performed using STATA software version 12.
Twelve case-control studies were included, seven investigating the association of sEH rs751141 polymorphism with ischemic stroke risk, and five examining its association with hypertension risk. The pooled odds ratios (OR) and 95% confidence intervals for the allelic, dominant, and recessive models of ischemic stroke risk were 1.167 (1.045-1.303, p = 0.006), 1.381 (1.104-1.883, p = 0.041), and 0.856 (0.753-0.9751, p = 0.019), respectively. For hypertension risk, the pooled OR values and 95% confidence intervals were 1.343 (1.229-1.467, p < 0.001), 1.537 (1.254-1.885, p < 0.001), and 0.715 (0.64-0.80, p < 0.001), respectively.
Carriers of the G allele of the sEH rs751141 polymorphism are at an increased risk for ischemic stroke and hypertension, while the A allele appears to have a protective effect against these conditions.
系统评价可溶性环氧化物水解酶（sEH）基因rs751141多态性与缺血性中风及高血压风险之间的关联。
检索截至2024年3月发表的符合条件的研究，数据库包括PubMed、Cochrane对照试验中心注册库、中国知网（CNKI）、万方数据和维普资讯。根据纳入和排除标准选择研究。使用纽卡斯尔-渥太华量表（NOS）和乔安娜·布里格斯研究所（JBI）工具评估纳入研究的质量。使用STATA 12软件进行数据提取和荟萃分析。
纳入12项病例对照研究，其中7项研究sEH rs751141多态性与缺血性中风风险的关联，5项研究其与高血压风险的关联。缺血性中风风险的等位基因、显性和隐性模型的合并比值比（OR）及95%置信区间分别为1.167（1.045 - 1.303，p = 0.006）、1.381（1.104 - 1.883，p = 0.041）和0.856（0.753 - 0.9751，p = 0.019）。对于高血压风险，合并OR值及95%置信区间分别为1.343（1.229 - 1.467，p < 0.001）、1.537（1.254 - 1.885，p < 0.001）和0.715（0.64 - 0.80，p < 0.001）。
sEH rs751141多态性G等位基因携带者患缺血性中风和高血压的风险增加，而A等位基因似乎对这些疾病具有保护作用。
