美西律在健康志愿者体内的非剂量依赖性药代动力学。
Dose independent pharmacokinetics of mexiletine in healthy volunteers.
作者信息
Pringle T, Fox J, McNeill J A, Kinney C D, Liddle J, Harron D W, Shanks R G
出版信息
Br J Clin Pharmacol. 1986 Mar;21(3):319-21. doi: 10.1111/j.1365-2125.1986.tb05196.x.
Abstract
In 12 healthy volunteers who received orally 100, 200, 300, 400 and 600 mg mexiletine at weekly intervals, the maximum plasma concentration of mexiletine and AUC increased linearly with the dose of mexiletine. Between doses there were no significant differences in the values for clearance and volume of distribution of mexiletine but there were for plasma elimination half-life. These results indicate that the kinetics of mexiletine are linear.
摘要
在12名健康志愿者中，他们每周口服100、200、300、400和600毫克美西律，美西律的最大血浆浓度和药时曲线下面积随美西律剂量呈线性增加。不同剂量之间，美西律的清除率和分布容积值无显著差异，但血浆消除半衰期有差异。这些结果表明美西律的动力学呈线性。
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