溶媒对环孢素口服吸收的影响。
The effect of vehicle on the oral absorption of cyclosporin.
作者信息
Johnston A, Marsden J T, Hla K K, Henry J A, Holt D W
出版信息
Br J Clin Pharmacol. 1986 Mar;21(3):331-3. doi: 10.1111/j.1365-2125.1986.tb05200.x.
Abstract
Twelve healthy volunteers received four separate doses of cyclosporin (5 mg kg-1). On three occasions the neat oil suspension (Sandimmun) was given dispersed in a different liquid vehicle and on one occasion the suspension was taken directly. Measurement of whole blood cyclosporin concentrations by radioimmunoassay showed no significant difference in the pharmacokinetic parameters of absorption between the neat preparation and the three dispersants used (milk, milk + chocolate flavouring and orange juice).
摘要
12名健康志愿者接受了4次不同剂量的环孢素（5毫克/千克）。其中3次给予的是纯油悬浮液（山地明），分别分散于不同的液体载体中，另1次直接服用该悬浮液。通过放射免疫分析法测定全血中环孢素浓度，结果显示纯制剂与3种分散剂（牛奶、牛奶+巧克力调味剂和橙汁）在吸收的药代动力学参数方面无显著差异。
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2
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