Langer A, Loveček M, Urban O, Kurfúrstová D, Kovář R, Mohelníková Duchoňová B
Rozhl Chir. 2024;103(11):454-457. doi: 10.48095/ccrvch2024454.
Pancreatic cancer is one of the most aggressive tumors diagnosed in local-ly advanced or metastatic stage in more than half of the cases. The standard of care is a systemic chemotherapy but the prognosis of metastatic patients remains extremely poor with a median overall survival less than one year. However, there is increasing evidence of surgery treatment benefit in a carefully selected oligometastatic cases. -Because oligometastatic pancreatic cancer is rare, there is a lack of robust clinical trials defining strategy, efficacy and safety of this procedure.
A 77-year-old man presented with a mass in the tail of the pancreas and solitary liver metastasis. After four cycles of chemotherapy, distal pancreatectomy with liver metastasectomy was performed, and the tissues were histologically examined. The complete pathological response was found in the primary tumor and residual adenocarcinoma in liver metastasis.
The patient is alive without recurrency more than two years from the diagnosis.
胰腺癌是最具侵袭性的肿瘤之一，超过半数病例在诊断时处于局部晚期或转移阶段。标准治疗方案是全身化疗，但转移性患者的预后仍然极差，中位总生存期不到一年。然而，越来越多的证据表明，在经过精心挑选的寡转移病例中，手术治疗有益。由于寡转移胰腺癌罕见，缺乏确定该手术策略、疗效和安全性的有力临床试验。
一名77岁男性因胰尾肿块和孤立性肝转移就诊。经过四个周期的化疗后，进行了远端胰腺切除术和肝转移灶切除术，并对组织进行了组织学检查。在原发性肿瘤和肝转移灶的残留腺癌中发现了完全病理缓解。
自诊断以来，患者已存活两年多且无复发。
