Venkataramanan Akash, Nayar Divya, Almasri Sama, Dhasakeerthi Thirumalaivasan, Jayachandran Sowmya, Bajaj Suryansh, Elangovan Cheran
Department of Internal Medicine, John H. Stroger, Jr. Hospital of Cook County Health, IL, USA.
Department of Neurology, University of Arkansas for Medical Sciences, AR, USA.
J Stroke Cerebrovasc Dis. 2025 Feb;34(2):108178. doi: 10.1016/j.jstrokecerebrovasdis.2024.108178. Epub 2024 Dec 6.
Stimulant use has been associated with an increased risk of stroke, though data on clinical characteristics and exact risk are limited. This retrospective case-control study examines stroke risk in individuals with stimulant use disorder using data from a national U.S.
Data was obtained from the 2019 National Readmission Database (NRD) using ICD-10 codes to identify relevant diagnoses. A multivariate logistic regression analyzed the impact of stimulant use disorder on stroke admission odds, adjusting for alcohol use disorder, tobacco use, diabetes, hypertension, dyslipidemia, age, insurance status, and median income. Outcomes like total hospitalization charge, length of stay, and in-hospital mortality were assessed with multivariate regression. Gender-specific analyses were also conducted. Statistical significance was set at p < 0.05.
A total of 4,821 adults with stimulant use disorder and stroke were compared to 542,618 stroke patients without stimulant use disorder. Patients with stimulant use disorder (PWSU) had significantly higher odds of hemorrhagic and ischemic stroke admissions, especially hemorrhagic strokes in women. PWSU with hemorrhagic strokes also had higher odds of in-hospital mortality.
Stimulant use disorder is associated with higher odds of admission for stroke, especially in women with an overall elevated mortality from hemorrhagic strokes. These findings underscore the need for further research and emphasize the importance of stroke prevention and treatment in individuals with stimulant use disorder.
使用兴奋剂与中风风险增加有关，尽管关于临床特征和确切风险的数据有限。这项回顾性病例对照研究利用美国国家数据，调查患有兴奋剂使用障碍的个体的中风风险。
数据来自2019年国家再入院数据库（NRD），使用国际疾病分类第十版（ICD - 10）编码来识别相关诊断。多变量逻辑回归分析了兴奋剂使用障碍对中风入院几率的影响，并对酒精使用障碍、烟草使用、糖尿病、高血压、血脂异常、年龄、保险状况和收入中位数进行了调整。通过多变量回归评估总住院费用、住院时间和院内死亡率等结果。还进行了性别特异性分析。统计学显著性设定为p < 0.05。
总共4821名患有兴奋剂使用障碍且中风的成年人与542618名没有兴奋剂使用障碍的中风患者进行了比较。患有兴奋剂使用障碍的患者（PWSU）发生出血性和缺血性中风入院的几率显著更高，尤其是女性的出血性中风。患有出血性中风的PWSU院内死亡几率也更高。
兴奋剂使用障碍与中风入院几率较高有关，尤其是在出血性中风导致总体死亡率升高的女性中。这些发现强调了进一步研究的必要性，并强调了对患有兴奋剂使用障碍的个体进行中风预防和治疗的重要性。
