Zheng Mei, Qu Jialin, Xiang Dongxi, Xing Ligang
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China.
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; Department of Biliary-Pancreatic Surgery, the Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189235. doi: 10.1016/j.bbcan.2024.189235. Epub 2024 Dec 6.
Brain metastasis stands as a leading contributor to mortality in lung cancer patients, yet the intricate mechanism underlying this phenomenon remains elusive. This underscores the need for robust preclinical models and effective treatment strategies. Emerging as viable in vitro models that closely replicate actual tumors, three-dimensional culture systems, particularly organoids derived from non-malignant cells or cancer organoids, have emerged as promising avenues. This review delves into the forefronts of fundamental research and clinical applications focused on lung cancer brain metastasis-derived organoids, highlighting current challenges and delineating prospects. These studies offer tremendous potential for clinical application despite being in nascent status.
脑转移是肺癌患者死亡的主要原因之一，然而这一现象背后的复杂机制仍然难以捉摸。这凸显了建立强大的临床前模型和有效治疗策略的必要性。三维培养系统作为能够紧密复制实际肿瘤的可行体外模型应运而生，特别是源自非恶性细胞的类器官或癌类器官，已成为有前景的途径。本综述深入探讨了聚焦于肺癌脑转移衍生类器官的基础研究和临床应用前沿，强调了当前的挑战并描绘了前景。尽管这些研究尚处于初期阶段，但它们具有巨大的临床应用潜力。
