Mikhalitskaya Ekaterina V, Vyalova Natalya M, Bokhan Nikolay A, Ivanova Svetlana A
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634014, Russia.
Biochemistry (Mosc). 2024 Nov;89(11):1889-1903. doi: 10.1134/S0006297924110038.
Chemokines are immunoregulatory proteins with pleiotropic functions involved in neuromodulation, neurogenesis, and neurotransmission. The way chemokines affect the CNS plays an important role in modulating various conditions that could have negative impact on CNS functions, including development of alcohol use disorders. In this review, we analyzed the literature data available on the problem of chemokine participation in pathogenesis, clinical presentation, and remission of alcohol use disorders both in animal models and in the study of patients with alcoholism. The presented information confirms the hypothesis that the alcohol-induced chemokine production could modulate chronic neuroinflammation. Thus, the data summarized and shown in this review are focused on the relevant direction of research in the field of psychiatry, which is in demand by both scientists and clinical specialists.
趋化因子是具有多效性功能的免疫调节蛋白，参与神经调节、神经发生和神经传递。趋化因子影响中枢神经系统的方式在调节各种可能对中枢神经系统功能产生负面影响的状况中起着重要作用，包括酒精使用障碍的发展。在本综述中，我们分析了有关趋化因子参与动物模型和酒精中毒患者研究中酒精使用障碍的发病机制、临床表现和缓解问题的现有文献数据。所呈现的信息证实了酒精诱导的趋化因子产生可调节慢性神经炎症这一假说。因此，本综述中总结和展示的数据聚焦于精神病学领域这一相关研究方向，这是科学家和临床专家都需要的。
