Lyu J J, Cai X, Lyu N, Zhang Y, Jiang X B, Ren M, Kong Y Y
Department of Pathology, Shanghai Cancer Center, Fudan University and Department of Oncology, Shanghai medical College, Fudan University, Shanghai200032, China.
Department of Pathology, Minhang Hospital, Fudan University, Shanghai201100, China.
Zhonghua Bing Li Xue Za Zhi. 2024 Dec 8;53(12):1224-1230. doi: 10.3760/cma.j.cn112151-20240731-00489.
To investigate the clinicopathological characteristics of spiradenocarcinoma, cylindrocarcinoma, and spiradenocylindrocarcinoma, and to understand the correlations between their morphological patterns and clinical behaviors. Seven cases of spiradenocarcinoma, cylindrocarcinoma, and spiradenocylindrocarcinoma diagnosed at Fudan University Shanghai Cancer Center, Shanghai, China from 2015 to 2021 were collected. The clinicopathological characteristics and follow-up data were retrospectively analyzed. Histopathologic evaluation and immunohistochemical studies were carried out. There were four men and three women in the cohort, with ages ranging from 46 to 75 years (mean, 61 years). The tumors were located on the head and neck (four cases), extremities (two cases), and trunk (one case). Histologically, the residuum of a benign neoplasm was present in all cases. One case presented salivary gland-type basal cell adenocarcinoma-like pattern, low-grade (BCAC-LG). Another case showed salivary gland-type basal cell adenocarcinoma-like pattern, high-grade (BCAC-HG). The remaining five cases were invasive adenocarcinoma, not otherwise specified (IAC-NOS). One of IAC-NOS contained a mucinous adenocarcinoma component. Immunohistochemically, BCAC-LG and BCAC-HG predominantly expressed basal cell markers such as p63 and p40, whereas IAC-NOS primarily exhibited positivity for CK7, a glandular epithelial marker. Follow-up was available for six patients, ranging from 1 to 9 years (mean, 4.5 years). Among the four patients of IAC-NOS with follow-up, three showed recurrences, two had regional lymph node metastases, and one died. The malignant components of spiradenocarcinomas, cylindrocarcinomas, and spiradenocylindrocarcinomas in this cohort contain BCAC-LG, BCAC-HG and IAC-NOS. This study also shows the presence of mucinous adenocarcinoma components in IAC-NOS. The tumors with IAC-NOS have a relatively poorer prognosis than those without.
研究汗腺癌、圆柱瘤及汗腺圆柱瘤的临床病理特征，了解其形态学模式与临床行为之间的相关性。收集了2015年至2021年在中国上海复旦大学附属肿瘤医院诊断的7例汗腺癌、圆柱瘤及汗腺圆柱瘤病例。对其临床病理特征及随访数据进行回顾性分析。进行了组织病理学评估和免疫组化研究。该队列中有4名男性和3名女性，年龄在46岁至75岁之间（平均61岁）。肿瘤位于头颈部（4例）、四肢（2例）和躯干（1例）。组织学上，所有病例均可见良性肿瘤残留。1例表现为涎腺型基底细胞腺癌样模式，低级别（BCAC-LG）。另1例表现为涎腺型基底细胞腺癌样模式，高级别（BCAC-HG）。其余5例为未另行特指的浸润性腺癌（IAC-NOS）。其中1例IAC-NOS包含黏液腺癌成分。免疫组化方面，BCAC-LG和BCAC-HG主要表达p63和p40等基底细胞标志物，而IAC-NOS主要对腺上皮标志物CK7呈阳性。6例患者有随访记录，随访时间为1至9年（平均4.5年）。在有随访记录的4例IAC-NOS患者中，3例出现复发，2例有区域淋巴结转移，1例死亡。该队列中汗腺癌、圆柱瘤及汗腺圆柱瘤的恶性成分包含BCAC-LG、BCAC-HG和IAC-NOS。本研究还显示IAC-NOS中存在黏液腺癌成分。有IAC-NOS的肿瘤预后相对较差。
