Söderström T, Enskog A, Samuelsson B E, Cedergren B
J Immunol. 1985 Jan;134(1):1-3.
Serum antibodies against globoside and ceramide trihexoside, two major glycolipids in human erythrocytes, were investigated in 29 individuals with the rare p blood group. Antibodies of the IgM and of the IgG3 classes were detected. In AB Rh(-) blood donors, who were not of the p blood group, low levels of antibodies of the IgM class were found against P and Pk, whereas no antibodies were detected in cord blood. The increased number of spontaneous abortions and stillbirths observed among the p individuals may relate to the presence of IgG3 antibodies, because such antibodies pass the placental barrier and are efficient in complement activation and in mediating antibody-dependent cytotoxicity.
对29名罕见p血型个体的血清中针对人红细胞中两种主要糖脂——红细胞糖苷脂和神经酰胺三己糖苷的抗体进行了研究。检测到了IgM和IgG3类抗体。在非p血型的AB Rh(-)献血者中，发现针对P和Pk的IgM类抗体水平较低，而在脐带血中未检测到抗体。在p血型个体中观察到的自然流产和死产数量增加可能与IgG3抗体的存在有关，因为这类抗体可穿过胎盘屏障，并且在补体激活和介导抗体依赖性细胞毒性方面很有效。
