Agbari Vidiatma, Hidayat Yudi Mulyana, Kurniadi Andi, Salima Siti, Harsono Ali B, Suardi Dodi, Yuseran Hariadi, Lisnasari Desy
Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Dr Hasan Sadikin General Hospital Bandung, Bandung, West Java, Indonesia.
Department of Obstetrics and Gynecology, Faculty of Medicine, Lambung Mangkurat University, Ulin Regional General Hospital, Banjarmasin, South Kalimatan, Indonesia.
Int J Womens Health. 2024 Dec 3;16:2077-2085. doi: 10.2147/IJWH.S486620. eCollection 2024.
Gestational Trophoblastic Neoplasia (GTN) has a high incidence in Bandung, Indonesia, with a mortality rate between 31% and 51%. The most common type is low-risk GTN with various treatment protocols available. The 8-day Methotrexate (MTX) 50 mg protocol has been implemented at our center; however, due to limitation of government insurance, this study aims to compare its effectiveness against the 1-day Methotrexate (MTX) 300 mg/m² protocol.
A retrospective cohort study compared two protocols for low-risk GTN treatment at Dr. Hasan Sadikin General Hospital from January 2020 to December 2023: a 1-day Methotrexate (MTX) 300 mg/m² protocol and an 8-day MTX protocol (50 mg MTX IM on days 1, 3, 5, 7 with folinic acid 15 mg orally 24 h after MTX on days 2, 4, 6, 8) and repeat every 2 weeks. Data on patient characteristics, chemotherapy response, side effects, and treatment costs were analyzed.
The 1-day MTX 300 mg/m² protocol achieved similar remission with fewer cycles, milder side effects, and reduced costs compared to the 8-day MTX 50 mg protocol, supporting it as an effective treatment option for low-risk GTN.
The 1-day MTX 300 mg/m² protocol is as an effective treatment option for low-risk GTN compared to the 8-day MTX 50 mg protocol.
妊娠滋养细胞肿瘤（GTN）在印度尼西亚万隆的发病率很高，死亡率在31%至51%之间。最常见的类型是低风险GTN，有多种治疗方案可供选择。我们中心已实施8天的甲氨蝶呤（MTX）50毫克方案；然而，由于政府保险的限制，本研究旨在比较其与1天的甲氨蝶呤（MTX）300毫克/平方米方案的有效性。
一项回顾性队列研究比较了2020年1月至2023年12月在哈桑·萨迪金综合医院治疗低风险GTN的两种方案：1天的甲氨蝶呤（MTX）300毫克/平方米方案和8天的MTX方案（第1、3、5、7天肌肉注射MTX 50毫克，第2、4、6、8天在MTX后24小时口服亚叶酸15毫克），每2周重复一次。分析了患者特征、化疗反应、副作用和治疗费用的数据。
与8天的MTX 50毫克方案相比，1天的MTX 300毫克/平方米方案在更少的周期内实现了相似的缓解，副作用更轻，成本更低，支持其作为低风险GTN的有效治疗选择。
与8天的MTX 50毫克方案相比，1天的MTX 300毫克/平方米方案是低风险GTN的有效治疗选择。
