Sun Qiu-Yue, Cheng Yi-Ming, Sun Yu-Hui, Huang Jin
Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213161, Jiangsu Province, China.
Department of Gastroenterology, Graduate School of Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
World J Gastrointest Surg. 2024 Nov 27;16(11):3538-3545. doi: 10.4240/wjgs.v16.i11.3538.
The treatment of benign biliary strictures (BBS) is a challenging clinical problem. At present, there is a lack of ideal models for the study of BBS treatment.
To develop a novel animal model of BBS to simulate studies on the processes and mechanisms in the human condition.
A rabbit model of benign bile duct stricture was established by surgical injury of the bile duct. After removal of the gallbladder, a drainage tube was placed through the cystic duct at the stump, and a BBS model was induced by surgical injury at the lower end of the common bile duct.
Compared with the control group, the model rabbits showed gross jaundice, increased serum bilirubin, and decreased liver function. Cholangiography showed segmental bile duct stenosis in the model rabbits. Pathological staining showed inflammatory cell infiltration and fibrosis in the biliary tract of rabbits in the model group. This was consistent with the clinical manifestations of BBS. This model provided serology, imaging, pathology, and other aspects of BBS.
We have successfully established an animal model of benign stricture of the lower bile duct with repeatable administration, which is consistent with the clinical manifestations of BBS.
良性胆管狭窄（BBS）的治疗是一个具有挑战性的临床问题。目前，缺乏用于研究BBS治疗的理想模型。
建立一种新型的BBS动物模型，以模拟对人类疾病过程和机制的研究。
通过胆管手术损伤建立兔良性胆管狭窄模型。切除胆囊后，经残端胆囊管置入引流管，在胆总管下端进行手术损伤诱导BBS模型。
与对照组相比，模型兔出现明显黄疸、血清胆红素升高及肝功能下降。胆管造影显示模型兔胆管节段性狭窄。病理染色显示模型组兔胆道有炎性细胞浸润和纤维化。这与BBS的临床表现一致。该模型提供了BBS的血清学、影像学、病理学等方面的表现。
我们成功建立了一种可重复给药的低位胆管良性狭窄动物模型，其与BBS的临床表现相符。
