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本文引用的文献

1
Diagnostic value of serum vascular endothelial growth factor and interleukin-17 in primary hepatocellular carcinoma.血清血管内皮生长因子和白细胞介素-17在原发性肝细胞癌中的诊断价值
World J Gastrointest Surg. 2024 Sep 27;16(9):2934-2941. doi: 10.4240/wjgs.v16.i9.2934.
2
Epidemiology of Hepatocellular Carcinoma in India - An Updated Review for 2024.印度肝细胞癌的流行病学——2024年最新综述
J Clin Exp Hepatol. 2024 Nov-Dec;14(6):101447. doi: 10.1016/j.jceh.2024.101447. Epub 2024 May 21.
3
IL-17A promotes the invasion-metastasis cascade via the AKT pathway in hepatocellular carcinoma.IL-17A 通过 AKT 通路促进肝癌的侵袭转移级联反应。
Mol Oncol. 2018 Jun;12(6):936-952. doi: 10.1002/1878-0261.12306. Epub 2018 Apr 26.
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Efficacy of anti-VEGF agents in the treatment of elderly hepatocellular carcinoma: a systematic review.抗血管内皮生长因子（VEGF）药物治疗老年肝细胞癌的疗效：一项系统评价
Oncotarget. 2017 Oct 3;8(54):93179-93185. doi: 10.18632/oncotarget.21452. eCollection 2017 Nov 3.
5
Serum AFU, 5'-NT and AFP as Biomarkers for Primary Hepatocellular Carcinoma Diagnosis.血清α-L-岩藻糖苷酶、5'-核苷酸酶和甲胎蛋白作为原发性肝细胞癌诊断的生物标志物。
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Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma.甲胎蛋白（AFP）、甲胎蛋白异质体-L3（AFP-L3）和异常凝血酶原（PIVKA-II）及其联合检测在肝细胞癌诊断中的应用价值
Medicine (Baltimore). 2017 Mar;96(11):e5811. doi: 10.1097/MD.0000000000005811.
7
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.全球癌症发病与死亡：GLOBOCAN 2012 数据源、方法与主要模式。
Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9.
8
Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring.肝细胞癌的影像学诊断、分期及治疗监测。
Cancer Imaging. 2013 Feb 8;12(3):530-47. doi: 10.1102/1470-7330.2012.0044.
9
Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma.去γ-羧基凝血酶原和甲胎蛋白作为肝癌早期检测的生物标志物。
Gastroenterology. 2010 Feb;138(2):493-502. doi: 10.1053/j.gastro.2009.10.031. Epub 2009 Oct 20.
10
Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma.岩藻糖基化糖蛋白作为原发性肝细胞癌生物标志物的鉴定与开发
J Proteome Res. 2009 Feb;8(2):595-602. doi: 10.1021/pr800752c.

释放血管内皮生长因子和白细胞介素-17的诊断潜力：推进肝细胞癌的早期检测策略

Unlocking the diagnostic potential of vascular endothelial growth factor and interleukin-17: Advancing early detection strategies for hepatocellular carcinoma.

作者信息

Subramanian Shanmathi, Rajakumar Hamrish Kumar

机构信息

Department of General Surgery, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nādu, India.

出版信息

World J Gastrointest Surg. 2024 Nov 27;16(11):3639-3642. doi: 10.4240/wjgs.v16.i11.3639.

DOI:10.4240/wjgs.v16.i11.3639
PMID:39649218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11622092/
Abstract

Tian investigated the diagnostic value of serum vascular endothelial growth factor (VEGF) and interleukin-17 (IL-17) in primary hepatocellular carcinoma (PHC). Their retrospective study, published in the , revealed that the serum levels of VEGF and IL-17 are significantly elevated in PHC patients compared with healthy controls. These biomarkers are closely associated with pathological features such as tumor metastasis and clinical tumor node metastasis stage. A receiver operating characteristic analysis further confirmed the diagnostic efficacy thereof, suggesting that VEGF and IL-17 could serve as valuable tools for early detection and treatment guidance. This study underscores the potential of integrating these biomarkers into clinical practice to increase diagnostic accuracy and improve patient management in PHC.

摘要

田研究了血清血管内皮生长因子（VEGF）和白细胞介素-17（IL-17）在原发性肝细胞癌（PHC）中的诊断价值。他们发表在[具体期刊名未给出]上的回顾性研究表明，与健康对照相比，PHC患者血清中VEGF和IL-17水平显著升高。这些生物标志物与肿瘤转移等病理特征以及临床肿瘤淋巴结转移分期密切相关。受试者工作特征分析进一步证实了其诊断效能，表明VEGF和IL-17可作为早期检测和治疗指导的有价值工具。本研究强调了将这些生物标志物整合到临床实践中以提高PHC诊断准确性和改善患者管理的潜力。