Lilly M B, Brezovich I A, Atkinson W J
Radiology. 1985 Jan;154(1):243-4. doi: 10.1148/radiology.154.1.3964942.
We have developed a self-regulating thermoseed for interstitial hyperthermia treatment of tumors. The seeds are made of a 70.4% nickel-29.6% copper alloy, and they have a Curie point at 50 degrees C. When exposed to an oscillating magnetic field (90 kHz, 50 Oersted amplitude), these seeds show a sharp drop in the rate of heat production at temperatures above the Curie point. In a simulated treatment of a small visceral mass that had negligible blood flow, the tissue temperature stabilized at the Curie point of the alloy with good temperature homogeneity throughout the volume heated by an array of thermoseeds.
我们已经开发出一种用于肿瘤间质热疗的自调节热籽。这些热籽由70.4%的镍 - 29.6%的铜合金制成，其居里点为50摄氏度。当暴露于振荡磁场（90千赫兹，50奥斯特振幅）时，这些热籽在温度高于居里点时产热速率会急剧下降。在对一个血流可忽略不计的小型内脏肿块进行模拟治疗时，组织温度在合金的居里点稳定下来，并且在由一组热籽加热的整个体积内具有良好的温度均匀性。
