Xia Chuan-Chao, Chen Hong-Tan, Deng Hao, Huang Yi-Ting, Xu Guo-Qiang
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
World J Gastroenterol. 2024 Dec 7;30(45):4771-4780. doi: 10.3748/wjg.v30.i45.4771.
Acute pancreatitis (AP) is a common acute gastrointestinal disorder affecting approximately 20% of patients with systemic inflammatory responses that may cause pancreatic and peripancreatic fat necrosis. This condition often progresses to multiple organ failure, significantly increasing morbidity and mortality. Oxidative stress, characterized by an imbalance between the body's reactive oxygen species (ROS) and antioxidants, activates the inflammatory signaling pathways. Although the pathogenesis of AP is not fully understood, ROS are increasingly recognized as critical in the disease's progression and development. Modulating the oxidative stress pathway has shown efficacy in mitigating the progression of AP. Despite numerous basic studies examining this pathway, comprehensive reviews of recent research remain sparse. This systematic review offers an in-depth examination of the critical role of oxidative stress in the pathogenesis and progression of AP and evaluates the therapeutic potential of antioxidant interventions in its management.
急性胰腺炎（AP）是一种常见的急性胃肠道疾病，约20%伴有全身炎症反应的患者会受其影响，可能导致胰腺及胰腺周围脂肪坏死。这种情况常进展为多器官功能衰竭，显著增加发病率和死亡率。氧化应激以体内活性氧（ROS）与抗氧化剂之间的失衡为特征，可激活炎症信号通路。尽管AP的发病机制尚未完全明确，但ROS在该疾病的进展和发展中日益被认为至关重要。调节氧化应激途径已显示出减轻AP进展的效果。尽管有大量基础研究探讨此途径，但对近期研究的全面综述仍然稀少。本系统综述深入探讨了氧化应激在AP发病机制和进展中的关键作用，并评估了抗氧化干预措施在其治疗中的潜力。
