Loforte Antonio, Marro Matteo, Simonato Erika, Costamagna Andrea, Ellena Marco, Trompeo Anna Chiara, Zanierato Marinella, Brazzi Luca, Rinaldi Mauro, Boffini Massimo
Department of Surgical Sciences, City of Health and Science University Hospital, Cardiac Surgery University Unit, University of Turin, Turin, Italy.
Department of Surgical Sciences and Department of Anesthesia and Critical Care, City of Health and Science University Hospital, University of Turin, Turin, Italy.
Ann Cardiothorac Surg. 2024 Nov 30;13(6):522-530. doi: 10.21037/acs-2024-dcd-26. Epub 2024 Nov 26.
In the last decade, heart transplants using allografts from adult donors after circulatory death, in a controlled setting, controlled donation after circulatory death (cDCD) have been rapidly adopted and widely performed. The selection of retrieval methods has largely been determined by state or institutional guidelines concerning permissible postmortem procedures. A significant majority of cDCD heart recoveries have employed direct procurement and perfusion (DPP) followed by normothermic machine perfusion (NMP) for graft preservation. Another established method involves the thoracoabdominal normothermic regional perfusion (taNRP), which is then followed by either NMP or static cold storage. Processing, management and surgical techniques of heart allograft procurement after cDCD are herein described and discussed.
在过去十年中,在可控环境下使用来自循环死亡后成年供体的同种异体移植物进行心脏移植,即循环死亡后可控捐赠(cDCD),已被迅速采用并广泛开展。获取方法的选择很大程度上由关于可允许的死后程序的州或机构指南决定。绝大多数cDCD心脏获取采用直接采购和灌注(DPP),随后进行常温机器灌注(NMP)以保存移植物。另一种既定方法涉及胸腹常温区域灌注(taNRP),随后进行NMP或静态冷藏。本文描述并讨论了cDCD后心脏同种异体移植物获取的处理、管理和手术技术。