Ferencz C, Rubin J D, McCarter R J, Brenner J I, Neill C A, Perry L W, Hepner S I, Downing J W
Am J Epidemiol. 1985 Jan;121(1):31-6. doi: 10.1093/oxfordjournals.aje.a113979.
The Baltimore-Washington Infant Study is a regional epidemiologic study of congenital heart disease. Among Infants born in the study area in 1981 and 1982, 664 had a diagnosis of congenital heart disease confirmed in the first year of life by echocardiography, cardiac catheterization, cardiac surgery, or autopsy. The prevalence rate was 3.7/1,000 livebirths for all cases and 2.4/1,000 livebirths for cases confirmed by invasive methods only. Diagnosis-specific prevalence rates of congenital heart disease are compared with those of eight previous case series. Changing diagnostic categorizations in the time span covered and methodological differences resulted in great variation of the data. However, the data of the New England Infant Cardiac Program which used the same case discovery methods showed similar occurrences of major morphologic abnormalities, suggesting that these are stable basic estimates in the eastern United States. For all case series, the rate of confirmed congenital heart disease was approximately 4/1,000 livebirths over the 40-year time span.
巴尔的摩-华盛顿婴儿研究是一项关于先天性心脏病的区域性流行病学研究。在1981年和1982年于研究区域出生的婴儿中，664名婴儿在出生后的第一年通过超声心动图、心导管检查、心脏手术或尸检确诊患有先天性心脏病。所有病例的患病率为3.7/1000活产，仅通过侵入性方法确诊的病例患病率为2.4/1000活产。将先天性心脏病的诊断特异性患病率与之前的八个病例系列进行了比较。在所涵盖的时间跨度内诊断分类的变化以及方法学上的差异导致数据有很大差异。然而，使用相同病例发现方法的新英格兰婴儿心脏项目的数据显示，主要形态学异常的发生率相似，这表明这些是美国东部稳定的基本估计值。在所有病例系列中，在40年的时间跨度内，确诊先天性心脏病的发生率约为4/1000活产。
