Rubin J D, Ferencz C, Brenner J I, Neill C A, Perry L W
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore 21201.
Am J Dis Child. 1987 Nov;141(11):1218-20. doi: 10.1001/archpedi.1987.04460110088031.
In an ongoing population-based study of congenital cardiovascular malformations in the Baltimore-Washington, DC, area, 1527 affected infants were ascertained from multiple sources during the years 1981 to 1984. Ninety-eight percent were evaluated at a regional pediatric cardiology center. Among the unreferred cases, in which the cardiac defect was diagnosed only at autopsy, most infants died in the first week of life and had associated problems, such as low birth weight, major noncardiac malformations, or other life-threatening illnesses, but a few infants with potentially remediable heart disease escaped clinical detection. Until preventive measures become available, reduction of infant mortality due to congenital cardiovascular malformations will continue to depend on early recognition of signs of serious heart disease in infants and on effective community-wide use of specialized cardiac services.
在一项针对巴尔的摩-华盛顿特区地区先天性心血管畸形的持续性人群研究中，1981年至1984年间，从多个来源确定了1527名患病婴儿。98%的婴儿在地区儿科心脏病中心接受了评估。在那些未被转诊的病例中，心脏缺陷仅在尸检时被诊断出来，大多数婴儿在出生后的第一周内死亡，并且伴有诸如低出生体重、严重非心脏畸形或其他危及生命的疾病等相关问题，但少数患有潜在可治愈心脏病的婴儿逃过了临床检测。在预防措施出现之前，降低先天性心血管畸形导致的婴儿死亡率将继续依赖于对婴儿严重心脏病体征的早期识别以及社区范围内对专业心脏服务的有效利用。
