Banisefid Erfan, Nasiri Ehsan, Pourebrahimian Leilabadi Seyedyashar, Hamzehzadeh Sina, Akbarzadeh Mohammad Amin, Hosseini Mohammad-Salar
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ann Med Surg (Lond). 2024 Oct 21;86(12):7221-7226. doi: 10.1097/MS9.0000000000002674. eCollection 2024 Dec.
is a microaerophilic gram-negative bacterium infecting around half of the world's population. Despite its well-known role in gastric malignancies, its impact on esophageal cancer comes with a complex paradox. Several mechanisms have been proposed to explain its observed lack of carcinogenic activity in the esophagus, including the trigger of anti-inflammatory pathways, promoting atrophic gastritis, and esophageal microbiome modulation. However, recent studies have highlighted a significantly more complicated interplay, where , typically considered a pathogen, may even deliver a protective effect against esophageal carcinogenesis. This paper aims to evaluate the prevalence of infection among patients with esophageal carcinoma, discussing the underlying mechanisms of the paradoxical effects of on esophageal cancer.
是一种微需氧革兰氏阴性菌，感染了全球约一半的人口。尽管其在胃癌中的作用广为人知，但其对食管癌的影响却存在复杂的矛盾。已经提出了几种机制来解释其在食管中观察到的缺乏致癌活性的现象，包括触发抗炎途径、促进萎缩性胃炎和调节食管微生物群。然而，最近的研究强调了一种明显更复杂的相互作用，其中通常被认为是病原体的，甚至可能对食管癌发生起到保护作用。本文旨在评估食管癌患者中感染的患病率，讨论对食管癌产生矛盾效应的潜在机制。
