Ramdam Niroj, Upadhya Pawan Sapkota, Luitel Prajjwol, Thapaliya Ishwor, Paudel Sujan, Kashyap Shiwangi, Karkee Rikesh Jung, Gupta Rakesh Kumar
Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan.
Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Ann Med Surg (Lond). 2024 Oct 16;86(12):6997-7001. doi: 10.1097/MS9.0000000000002670. eCollection 2024 Dec.
The global incidence of benign prostatic hyperplasia (BPH) is rising, with bacterial causes of lower urinary tract symptoms (LUTS) being a common factor contributing to complications in these patients.
To identify the prevalence of bacteriuria and treatment response in patients with symptomatic BPH.
This 1-year prospective study included all patients presenting with LUTS due to BPH who met the inclusion criteria. Urine samples were collected and analyzed for microscopy, culture, and sensitivity following standard protocols. Bacterial growth in urine specimens and International Prostate Symptom Score (IPSS) of LUTS were recorded before and after antibiotic therapy.
A total of 131 patients with symptomatic BPH were studied. Escherichia coli (47.6%) was the most commonly isolated bacteria, followed by and species. and showed the highest sensitivity to nitrofurantoin. After 1 week of antibiotic therapy, 69% of patients had sterile urine cultures, while 31% remained positive. Significant improvement in IPSS scores was observed after 1 week of therapy (<0.05), and there was no significant change in urine culture (=0.854).
Bacteriuria is a common finding in patients with symptomatic BPH in our setting. and were the most frequently isolated organisms, with sensitivity to nitrofurantoin and cefixime. A week of antibiotic therapy significantly reduced IPSS scores but did not reduce bacteriuria.
良性前列腺增生（BPH）的全球发病率正在上升，下尿路症状（LUTS）的细菌病因是这些患者发生并发症的常见因素。
确定有症状的BPH患者的菌尿症患病率和治疗反应。
这项为期1年的前瞻性研究纳入了所有因BPH出现LUTS且符合纳入标准的患者。按照标准方案收集尿液样本并进行显微镜检查、培养和药敏分析。记录抗生素治疗前后尿液标本中的细菌生长情况以及LUTS的国际前列腺症状评分（IPSS）。
共研究了131例有症状的BPH患者。大肠埃希菌（47.6%）是最常分离出的细菌，其次是[此处原文缺失两种细菌名称]。[此处原文缺失两种细菌名称]对呋喃妥因的敏感性最高。抗生素治疗1周后，69%的患者尿液培养无菌，而31%的患者仍为阳性。治疗1周后观察到IPSS评分有显著改善（<0.05），尿液培养无显著变化（=0.854）。
在我们的研究环境中，菌尿症在有症状的BPH患者中很常见。[此处原文缺失两种细菌名称]是最常分离出的微生物，对呋喃妥因和头孢克肟敏感。一周的抗生素治疗显著降低了IPSS评分，但并未降低菌尿症。
