Scheithauer B W, Randall R V, Laws E R, Kovacs K T, Horvath E, Whitaker M D
Cancer. 1985 Feb 1;55(3):598-604. doi: 10.1002/1097-0142(19850201)55:3<598::aid-cncr2820550320>3.0.co;2-s.
A patient with a primary adenohypophyseal neoplasm who had a long course marked by multiple surgical resections, radiation therapy, and high-dose dopamine agonist therapy developed local invasion as well as cranial and extracranial osseous metastatic lesions. The serum prolactin levels were greatly elevated, and immunohistochemical studies demonstrated prolactin in the cytoplasm of primary and metastatic tumor cells. Ultrastructural features of lactotrophic differentiation, including misplaced granule exocytosis, were observed. This is the third reported case of prolactin cell carcinoma that metastasized despite high-dose dopamine agonist therapy. Analysis of the patient's serum prolactin showed no abnormality in the chromatographic profile of biologic activity.
一名患有原发性腺垂体肿瘤的患者病程漫长，经历了多次手术切除、放射治疗和高剂量多巴胺激动剂治疗，出现了局部侵袭以及颅骨和颅外骨转移病变。血清催乳素水平大幅升高，免疫组织化学研究显示原发性和转移性肿瘤细胞的细胞质中有催乳素。观察到了催乳素细胞分化的超微结构特征，包括错位的颗粒胞吐作用。这是第三例报告的催乳素细胞癌病例，尽管接受了高剂量多巴胺激动剂治疗仍发生了转移。对患者血清催乳素的分析显示其生物活性的色谱图谱无异常。
