Petterson T, MacFarlane I A, MacKenzie J M, Shaw M D
Department of Endocrinology, Walton Hospital, Liverpool, UK.
J Neurol Neurosurg Psychiatry. 1992 Dec;55(12):1205-6. doi: 10.1136/jnnp.55.12.1205.
A man with a prolactin secreting pituitary carcinoma was treated by surgery and radiotherapy. Persistent hyperprolactinaemia partially responded to oral bromocriptine for four years. Serum prolactin then rose considerably with rapid, invasive tumour recurrence. Cytotoxic chemotherapy halted tumour progression for twelve months before fatal spread throughout the brain. Failure to normalise serum prolactin with bromocriptine may precede an aggressive course in patients with prolactinoma.
一名患有分泌催乳素的垂体癌男性患者接受了手术和放疗。持续性高催乳素血症对口服溴隐亭部分有效，持续了四年。随后血清催乳素大幅上升，肿瘤迅速复发并呈侵袭性生长。细胞毒性化疗使肿瘤进展停止了十二个月，之后肿瘤在脑部广泛转移导致患者死亡。对于催乳素瘤患者，溴隐亭未能使血清催乳素恢复正常可能预示着病情将进展迅速。
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