Roush G C, Fischer D B, Flannery J T
Cancer. 1985 Feb 1;55(3):666-71. doi: 10.1002/1097-0142(19850201)55:3<666::aid-cncr2820550332>3.0.co;2-r.
In previous reports on scrotal carcinomas, overall 5-year survival rates have varied from 18% to 70% without explanation. In this study, survival was determined through the active follow-up of the Connecticut Tumor Registry for 65 cases of scrotal carcinoma diagnosed in the state from 1935 to 1980. The overall actuarial probability of surviving 5 years was 0.57. Stage and age at diagnosis were statistically significant predictors of survival (P less than 0.001 and P = 0.016, respectively). Survival varied progressively with combinations of these two variables with subjects younger than age 65 years and localized at diagnosis having 5-year survival of 0.75, compared to 0.17 for subjects age 65 years and older with regional or distant spread; these survival outcomes encompassed those of previous reports. With the passage of more than four decades, no improvement in survival was detectable. Initial radiotherapy, given to nine cases, also bore no detectable relationship to survival after adjustment for other variables. The 30 men in metalworking occupations previously shown to be associated with this cancer were not more frequently diagnosed with the cancer in localized stage, and showed a survival similar to that for the 29 men in other occupations.
在以往关于阴囊癌的报告中，总体5年生存率在18%至70%之间波动，且无相关解释。在本研究中，通过对康涅狄格肿瘤登记处进行积极随访，确定了1935年至1980年该州诊断出的65例阴囊癌患者的生存情况。总体5年生存的精算概率为0.57。诊断时的分期和年龄是生存的统计学显著预测因素（分别为P<0.001和P = 0.016）。生存情况随着这两个变量的组合而逐渐变化，诊断时年龄小于65岁且为局限性病变的患者5年生存率为0.75，而年龄65岁及以上且有区域或远处转移的患者5年生存率为0.17；这些生存结果涵盖了以往报告中的情况。经过四十多年，未发现生存率有改善。对9例患者进行了初始放疗，在对其他变量进行调整后，放疗与生存也无明显关联。之前显示与这种癌症相关的30名从事金属加工职业的男性，在局限性阶段被诊断出患癌的频率并不更高，且其生存率与其他职业的29名男性相似。
