Motl Robert W, Sandroff Brian M, Hernandez Roberto S, Amato Maria Pia, Brichetto Giampaolo, Chataway Jeremy, Chiaravalloti Nancy D, Cutter Gary, Dalgas Ulrik, DeLuca John, Farrell Rachel, Feys Peter, Filippi Massimo, Freeman Jennifer, Inglese Matilde, Meza Cecilia, Rocca Maria A, Salter Amber, Feinstein Anthony
Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.
Kessler Foundation, West Orange, NJ, USA.
Mult Scler J Exp Transl Clin. 2024 Dec 5;10(4):20552173241301030. doi: 10.1177/20552173241301030. eCollection 2024 Oct-Dec.
There is heterogeneity of aerobic fitness (VO) changes with a standardized exercise training stimulus in the general population (i.e. some participants demonstrate improvements, others no change, and some a reduction in VO).
This secondary, exploratory analysis of data examined the heterogeneity of VO responses and possible correlates among persons with progressive multiple sclerosis (PMS) from the CogEx trial.
CogEx was a multi-site, multi-arm, randomized, double-blinded, and sham-controlled trial undertaken by 11 sites in six different countries. Participants were randomized into one of four conditions with different combinations of exercise training and cognitive rehabilitation including respective sham conditions. The analysis focuses primarily on VO change for the pooled exercise training intervention conditions compared with the pooled sham exercise control conditions.
Waterfall plots for change in VO suggested greater heterogeneity with exercise training than sham, and the proportions of difference in VO change (i.e. improvement/worsening) were significantly different between exercise training and sham conditions( < 0.05). The multivariable analysis indicated that lower baseline VO ( < 0.001) was the only statistically significant correlate of increases in VO with exercise training.
Our results highlight the heterogeneity of change in VO with exercise training that is correlated with initial aerobic capacity in PMS, and such results may inform hypothesis testing in future clinical trials of exercise training.
在普通人群中，标准化运动训练刺激下有氧适能（VO）的变化存在异质性（即一些参与者表现出改善，另一些没有变化，还有一些VO下降）。
这项对数据的二次探索性分析研究了来自CogEx试验的进行性多发性硬化症（PMS）患者VO反应的异质性以及可能的相关因素。
CogEx是一项由六个不同国家的11个地点进行的多地点、多组、随机、双盲和假对照试验。参与者被随机分配到四种不同运动训练和认知康复组合的条件之一，包括各自的假对照条件。分析主要集中在将合并的运动训练干预条件下的VO变化与合并的假运动对照条件进行比较。
VO变化的瀑布图表明，与假对照相比，运动训练的异质性更大，运动训练和假对照条件之间VO变化差异的比例（即改善/恶化）有显著差异（<0.05）。多变量分析表明，较低的基线VO（<0.001）是运动训练后VO增加的唯一具有统计学意义的相关因素。
我们的结果突出了运动训练后VO变化的异质性，这与PMS患者的初始有氧能力相关，这些结果可能为未来运动训练临床试验中的假设检验提供信息。
