Takano Atsushi, Nakamaru Yuta, Sako Ken-Ichi, Takano Asuka, Iga Masanori, Machida Mitsuru, Kaku Teppei, Ishimura Atsushi, Nakasuga Hirotaka, Matsuda Yoshikazu, Fujikake Yoshio, Maeda Tomoji
Department of Pharmacy, Saitama Red Cross Hospital, Saitama 330-8553, Japan.
Department of Clinical Pharmacy, Nihon Pharmaceutical University, Saitama 362-0806, Japan.
Biomed Rep. 2024 Nov 21;22(2):17. doi: 10.3892/br.2024.1895. eCollection 2025 Feb.
Comprehensive electrolyte infusions containing amino acids, including BFLUID, are a source of nosocomial infections caused by . It is recommended that clinicians finish the administration of BFLUID within 6 h; however, this recommendation currently lacks supporting empirical evidence. Accordingly, the present study aimed to investigate the risk of infection associated with BFLUID infusion according to the administration time. In the present single-center retrospective observational cohort study, clinical information was extracted from the medical records of patients aged ≥18 years who received BFLUID infusions via a peripheral line between April 2017 and October 2020 at Saitama Red Cross Hospital (Saitama, Japan). A total of 96 patients were enrolled during the study period, of whom 32 developed infection. No patients with BFLUID infusions administered within 6 h developed infection. Compared with patients who received BFLUID infusions within 8 h, those who received BFLUID infusions after 8 h had a 7-fold higher risk of infection. The present study provided empirical evidence supporting the recommendation that amino acid infusions should be administered to patients within 6 h to minimize the risk of infection.
包含氨基酸的综合性电解质输注液，包括BFLUID，是由……引起的医院感染的一个来源。建议临床医生在6小时内完成BFLUID的输注；然而，这一建议目前缺乏实证依据。因此，本研究旨在根据输注时间调查与BFLUID输注相关的感染风险。在本单中心回顾性观察队列研究中，从2017年4月至2020年10月期间在日本埼玉红十字医院（埼玉）通过外周静脉接受BFLUID输注的年龄≥18岁患者的病历中提取临床信息。研究期间共纳入96例患者，其中32例发生了……感染。在6小时内输注BFLUID的患者中没有发生……感染。与在8小时内接受BFLUID输注的患者相比，在8小时后接受BFLUID输注的患者感染风险高7倍。本研究提供了实证依据，支持应在6小时内为患者输注氨基酸以将……感染风险降至最低的建议。
