Kelley Brendan J, Bailey Kala J, Hubregsen Joshua J
From the Departments of Neurology.
Psychiatry, University of Texas Southwestern, Dallas, TX.
J ECT. 2025 Jun 1;41(2):e18-e20. doi: 10.1097/YCT.0000000000001093. Epub 2024 Dec 3.
Down syndrome regression disorder (DSRD) is a condition in which individuals with Down syndrome experience a decline in social and adaptive functioning in adolescence to early adulthood. Initially described as catatonic psychosis and later designated Down syndrome disintegrative disorder (DSDD), the etiology for DSRD remains unclear but has been hypothesized to relate to autoimmune function, stress, and psychiatric disease. DSRD presents heterogeneously and has no clearly established diagnostic criteria, which can complicate treatment recommendations. ECT has been used to successfully treat DSRD, but the number of reported cases remains low, especially when it is unclear whether there are comorbid catatonic features. Here, we present a case of successful use of ECT in an individual with DSRD in which catatonic features were difficult to ascertain, and we make recommendations for the use of ECT in the treatment of DSRD.
唐氏综合征退行性障碍（DSRD）是一种唐氏综合征患者在青春期至成年早期社会和适应功能出现衰退的病症。最初被描述为紧张性精神病，后来被命名为唐氏综合征解体性障碍（DSDD），DSRD的病因尚不清楚，但据推测与自身免疫功能、压力和精神疾病有关。DSRD表现各异，且没有明确确立的诊断标准，这可能使治疗建议变得复杂。电休克治疗（ECT）已成功用于治疗DSRD，但报告的病例数量仍然较少，尤其是在难以确定是否存在共病的紧张性特征时。在此，我们介绍一例成功使用ECT治疗DSRD患者的病例，该患者的紧张性特征难以确定，并对ECT在DSRD治疗中的应用提出建议。
